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keratolytics in the tretment of dermatophytosis

The Efficacy oral Terbinafine alone and combined with 20% topical urea in the treatment of Pediatric Dermatophytosis and Prevention of Chronicity and Recurrence. A double-blind Randomized control trail.

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250815003
Enrollment
140
Registered
2025-08-15
Start date
2025-11-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dermatophystosis Dermatophytosis, Keratolytics, Terbinafine, ,Urea

Interventions

this group received oral terbinafine in combination with 20% topical urea for 6 weeks l terbinafine only,This group received oral terbinafine only for 6 weeks
Active Comparator Drug,Active Comparator Drug
treatment/drugs,treatment/drugs

Sponsors

Lady reading hospital peshawar,Pakistan
Lead Sponsor

Eligibility

Sex/Gender
All
Age
2 Years to 16 Years

Inclusion criteria

Inclusion criteria: 1.All patients with dermatophytes infection diagnosed on clinical grounds and potassium hydroxide mount(KOH examination) 2. between age2-16 and willing to participate in the study.

Exclusion criteria

Exclusion criteria: 1.Patients with diabetes mellitus or any other immunosuppression 2. having history of sensitivity to terbinafine or topical urea 3. patients with past or current hepatitis or other liver diseases were considered ineligible for the trial 4. Finally, patients with T.capitis and onychomycosis were not considered due to altered disease course and prolonged treatment regimes.

Design outcomes

Primary

MeasureTime frame
clinical cure 6 weeks Clinical examination/ Potassium Hydroxide Mount(KOH mount)

Secondary

MeasureTime frame
prevention of recurrence and chronicity 6 months Clinical examination/Potassium Hydroxide Mount(KOH mount)

Countries

Pakistan

Contacts

Public ContactMuhammad Fahim

Lady reading hospital peshawar

clinicaldermatologist@gamil.com03465354921

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026