Opportunistic infections in immunocompetent host with Anti GM CSF autoantibodies Opportunistic infections in immunocompetent host, Anti GM CSF autoantibodies, HLA typing, Cryptococcosis
Conditions
Interventions
Immunocompetent patient with opportunistic infections with Anti GM CSF autoantibodies
Diagnostic
Anti GM CSF autoantibodies positive
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Participants aged 18 years or older 2. Diagnosed with Cryptococcosis or Nocardiosis or Histoplasmosis or Talaromycosis or Aspergillosis
Exclusion criteria
Exclusion criteria: 1. Participants with HIV infection 2. Participants with cancer 3. Participants who have undergone organ transplantation 4. Participants who have undergone stem cell transplantation 5. Participants with a history of corticosteroid or immunosuppressive drug use 6. Participants with a history of splenectomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the prevalence of anti-GM-CSF autoantibodies in patients with opportunistic infections without immunodeficiency retrospective chart review for data collection since 1st January 2018, and prospective data collection for 2 years Number, percentage, and 95% confidence interval | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the clinical characteristics and treatment outcomes of cryptococcosis and other opportunistic infections in immunocompetent Thai patients with anti-GM-CSF autoantibodies retrospective chart review for data collection since 1st January 2018, and prospective data collection for 2 years Number, percentage, and 95% confidence interval,To determine the HLA typing of cryptococcosis patients with anti-GM-CSF autoantibodies prospective data collection for 2 years nominal data | — |
Countries
Thailand
Contacts
Public ContactMethee Chayakulkeeree
Faculty of Medicine Siriraj Hospital
Outcome results
None listed