preventing PONV in patients who underwent MVD surgery Microvascular decompression surgery (MDV) Postoperative nausea and vomiting (PONV) Propofol infusion
Conditions
Interventions
induction by Target Controlled Infusions ( TCI) of propofol infusion, Monitor Bispectral index, keep value between 40- 60
maintenance anesthesia with Target Controlled Infusions (TCI) of propofol inf
TIVA with Propofol,Sevoflurane
Sponsors
Khon Kaen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old 2. ASA physical status I III
Exclusion criteria
Exclusion criteria: 1. refuse to participate 2. History of PONV, motion sickness 3. Known allergies to study drugs: propofol, dexamethasone, ondansetron 4. Chronic use/ recent administration of antiemetic drugs within 24 h 5. Impaired liver (> Child-Pugh class B) or kidney function (eGFR < 30 mL/min/1.73m2) 6. Pregnancy 7. BMI <18-35 > mg/m2 8. Emergency surgery 9. Unstable hemodynamics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and episodes of nausea and vomiting At first 1 hr, At 1 - 24 hr patient report e.g Nausea/Vomiting (N/V) score (0-3) | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of postoperative nausea and vomiting 1st to the 24th hour postoperatively observe patient clinical ,amount of requested antiemetic 1st to the 24th hour postoperative medical record , amount of requested opioid drugs. 1st to the 24th hour postoperative medical record ,Times from reversal to Extubation emergence phase observe clinical patient ,Times from reversal to Eye opening to command emergence phase observe clinical patient ,Times from reversal to Purposeful responses to verbal command emergence phase observe patient clinical ,Hypotension intraoperative anesthetic record ,Awareness intraoperative Patient reported ,Brain edema intraoperative report by surgeon,Patient satisfaction at 24 hour postoperative Patient reported outcome using a questionnaire interview | — |
Countries
Thailand
Contacts
Public ContactPimol Laohawee
Department of Anesthesiology, Faculty of Medicine, Khon Kaen University
Outcome results
None listed