Patients presenting to the emergency department with nausea Nausea Ammonia Inhalation
Conditions
Interventions
Place 3 milliliters of either 10% concentrated ammonia solution onto a sterile 2x2 inch gauze pad, then seal it in an opaque foil zip lock bag bag measuring 8.5 x 14 centimeters. Hold the gauze pad 2.
Experimental Drug,Placebo Comparator Drug
Ammonia,isopropyl alcohol
Sponsors
Faculty of medicine, Vajira hospital, Navamindradhiraj university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 65 years 2. Nausea visual analog scale of 4 to 8 3. Emergency severity index 3 and 4 4. Able to communicate in Thai 5. No history of allergy to ammonia and isopropyl alcohol
Exclusion criteria
Exclusion criteria: 1. Nausea and vomiting caused by surgical conditions 2. Pregnancy 3. Inability to breathe through the nose 4. Received antiemetic medication within 24 hours before the start of the study 5. Ingestion of drugs or foods that may cause a disulfiram-like reaction, such as metronidazole, cephalosporins, griseofulvin, isoniazid, durian, or certain mushrooms (e.g., ink cap mushrooms Coprinus spp.) 6. Chronic lung diseases, such as asthma or emphysema 7. Altered mental status 8. History of abnormal prolonged QT interval on electrocardiogram (QT prolongation) 9. Suspected nausea and vomiting due to increased intracranial pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| nausea visual analog at minute 0, minute 2, minute 4, minute 10, and minute 15 after inhalation nausea visual analog | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse effects 15 minutes after imhalation symptoms | — |
Countries
Thailand
Contacts
Public Contactsupa niruntarai
Navamindradhiraj university
Outcome results
None listed