Understanding Who Gets Duodenal Ulcer Perforation and How Often Its Linked to a Stomach Bacteria (H. pylori)

A cross-sectional study of demographic profile and incidence of Helicobacter pylori in patients with duodenal ulcer perforation.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20250807002

Enrollment

Registered

2025-08-07

Start date

2024-03-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Duodenal ulcer perforation Peptic ulcer disease Helicobacter pylori infection Peritonitis Nonsteroidal anti-inflammatory drug related ulcer Gastrointestinal perforation Acute abdomen Helicobacter pylori infection duodenal ulcer perforation peptic ulcer disease gastrointestinal perforation risk factors, smoking alcohol consumption NSAIDs, socioeconomic status histopathology, Giemsa stain emergency surgery abdominal pain peritonitis omental patch repair acute abdomen developing countries

Interventions

A multidisciplinary research team focused on studying the demographic profile and incidence of Helicobacter pylori infection in patients with duodenal ulcer perforation. The group aims to improve unde

Diagnostic

Duodenal ulcer perforation patients

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients between 18-70 years of age. Patients having perforated duodenal ulcers.

Exclusion criteria

Exclusion criteria: Patients younger than 18 or older than 70 years Recent use of antibiotics, PPIs, or H2 receptor antagonists within 4 weeks before admission Gastric ulcers or malignancy related perforation Hollow viscus perforation other than DUP Traumatic duodenal perforation

Design outcomes

Primary

Measure	Time frame
Incidence of Helicobacter pylori infection Type At the time of surgery (intraoperative) Histopathological examination (HPE) using Giemsa stain on biopsy from ulcer edge,Association of risk factors (Analytical) At enrollment and history taking Patient interview and clinical record (smoking, alcohol, NSAIDs, SES)	—

Secondary

Measure	Time frame
Age and sex distribution (Descriptive) At enrollment (presentation) Recorded from patient demographics,Perforation size and site Intraoperative During surgery Measured with ruler and noted by surgeon,Radiologic detection (pneumoperitoneum) (Diagnostic) Preoperative investigations Erect chest X-ray or CECT scan	—

Countries

Nepal

Contacts

Public ContactSamrat Shrestha

National Academy of Medical Sciences

samratshrestha431@gmail.com9845152204

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026