Perioperative Tranexamic Acid (TXA) Administration in Metabolic Bariatric Surgery to Reduce Perioperative bleeding: A Double-blinded, 3-arm Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250803003

Enrollment

126

Registered

2025-08-03

Start date

2024-06-25

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To evaluate the effect of Tranexamic Acid (TXA) administration in perioperative bleeding, postoperative respiratory-related pain, and prolonged hospital stay in patients undergoing laparoscopic sleeve gastrectomy (LSG) Laparoscopic sleeve gastrectomy, bariatric surgery, obesity, bleeding, tranexamic acid, bariatric

Interventions

Non TXA - placebo (Normal saline 0.9%) ,Patients receiving IV TXA 1g 30 minutes prior to induction , Patients receiving IV TXA 1g 30 minutes prior to induction + 3 regular dose 8 hours apart of IV TXA

Placebo Comparator Drug,Active Comparator Drug,Active Comparator Drug

Group 1 - Controlled group,Group 2 - TXA,Group 3 - TXA3

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing laparoscopic sleeve gastrectomy (LSG) 2. American Society of Anesthesiology (ASA) Classification I and II 3. 18 to 65 years old

Exclusion criteria

Exclusion criteria: 1. Patients with underlying hematological/coagulation disorder 2. Patients on antiplatelet 3. Patients with contradiction/allergic to contents in TXA 4. Previous history of VTE 5. Previous abdominal surgery except lower segment cesarean section (LSCS)/ gynaecological procedure 6. Patients with underlying IHD, CKD stage IIIB and above

Design outcomes

Primary

Measure	Time frame
Intra operative bleeding intraoperative Gauze weight,The amount of hemostatic sutures used to secure bleeding intraoperative Number of sutures,Pre and postoperative hemoglobin counts Pre and post operative Hemoglobin level	—

Secondary

Measure	Time frame
Length of hospital stay After discharge Days of hospital stay post operatively,Adverse effect and complications Pre/Intra and post operative Documented using proforma,Pain score Postoperative Visual Analogue Score (VAS),Spirometry efforts Postoperative Spirometry reading	—

Countries

Malaysia

Contacts

Public ContactMang Ning Ong

Hospital Canselor Tuanku Muhriz

katherinneong@gmail.com60122828711

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026