Idiopathic normal pressure hydrocephalus (iNPH) Parkinson disease (PD) stage 2-3 Healthy controls were recruited to serve as a reference data in comparison to patients with iNPH and PD Normal Pressure Hydrocephalus Parkinson Disease Gait Incoordination
Conditions
Interventions
Patients diagnosed with iNPH based on clinical and neuroimaging findings by neurosurgeon.,Patients diagnosed with idiopathic PD based on clinical findings and response to medication by neurologist.,Ag
Idiopathic Normal Pressure Hydrocephalus (iNPH),Parkinson Disease (PD),Healthy controls (HC)
Sponsors
Faculty of Physical Therapy, Mahidol University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Individuals with iNPH 1.1 Age between 60 to 85 years 1.2 Male or female 1.3 Clinically diagnosed as iNPH by neurologists or neurosurgeons. 1.4 Underwent CSF shunt surgery. 1.5 Able to walk independently without any device for at least 1 minute. 1.6 Able to understand and follow commands. 1.7 Able to perform basic arithmetic operations. 2. Individuals with PD 2.1 Age between 60 to 85 years 2.2 Male or female 2.3 Clinically diagnosed as PD stages 2 to 3 as assessed by the modified Hoehn and Yahr scale 2.4 Having stable PD medication usage for at least 1 month. 2.5 Taking PD medication no longer than 30 minutes to 1 hour before testing. 2.6 Able to walk independently without any device for at least 1 minute. 2.7 Able to understand and follow commands. 2.8 Able to perform basic arithmetic operations. 3. Healthy control 3.1 Age between 60 to 85 years 3.2 Male or female 3.3 Able to walk independently without any device at least 1 minute. 3.4 Able to understand and follow commands. 3.5 Able to perform basic arithmetic operations.
Exclusion criteria
Exclusion criteria: 1. Individuals with iNPH 1.1 Diagnosed with other neurological diseases, such as PD, Spinal Cord Injury (SCI), Multiple Sclerosis (MS), or Motor Neuron Disease (MND). 1.2 Presence of severe cardiopulmonary disease. 1.3 Presence of severe musculoskeletal problems such as severe osteoarthritis, deformities, and contractures in lower limbs with moderate to severe pain defined by a score of Visual Analog Scale (VAS) >= 4/10. 1.4 Presence of severe cognitive impairment, which was assessed using the Montreal Cognitive Assessment Thai version (MoCA) with a score < 10/30 1.5 Completely unable to perform the subtraction task in the attention domain of the MoCA. 1.6 A leg length discrepancy > 2 cm. 1.7 Unstable vital signs (blood pressure more than 160/90 mmHg and heart rate < 59 beats/min or > 90 beats/min) 1.8 Visual or auditory impairments after correction by glasses or hearing aids. 2. Individuals with PD 2.1 Diagnosed with other neurological diseases, such as SCI, MS, or MND. 2.2 Presence of severe cardiopulmonary disease. 2.3 Presence of any neurological disease and severe cardiopulmonary disease. 2.4 Presence of severe musculoskeletal problems such as severe osteoarthritis, deformities, and contractures in lower limbs with moderate to severe pain defined by a score of Visual Analog Scale (VAS) >= 4/10. 2.5 Presence of severe cognitive impairment, which was assessed using the Montreal Cognitive Assessment Thai version (MoCA) with a score <10/30. 2.6 Completely unable to perform the subtraction task in the attention domain of the MoCA. 2.7 A leg length discrepancy > 2 cm. 2.8 Unstable vital signs (blood pressure more than 160/90 mmHg and heart rate < 59 beats/min or > 90 beats/min) 2.9 Visual or auditory impairments after correction by glasses or hearing aids. 2.10 Severe dyskinesia 3. Healthy control 3.1 Diagnosed with other neurological diseases, such as iNPH, PD, SCI, MS, or MND. 3.2 Presence of severe cardiopulmonary disease. 3.3 Presence of severe musculoskeletal problems such as severe osteoarthritis, deformities, and contractures in lower limbs with moderate to severe pain defined by a score of Visual Analog Scale (VAS) >= 4/10. 3.4 Presence of severe cognitive impairment, which was assessed using the Montreal Cognitive Assessment Thai version (MoCA) with a score <10/30. 3.5 Completely unable to perform the subtraction task in the attention domain of the MoCA.A leg length discrepancy > 2 cm. 3.6 Unstable vital signs (blood pressure more than 160/90 mmHg and heart rate < 59 beats/min or > 90 beats/min) 3.7 Visual or auditory impairments after correction by glasses or hearing aids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bilateral gait coordination At a single time point with multiple conditions including comfortable speed, fast speed, single-task, and dual-task. Phase Coordination Index (PCI),Interlimb gait coordination At a single time point with multiple conditions including comfortable speed, fast speed, single-task, and dual-task. Cross correlation (X-corr) | — |
Secondary
| Measure | Time frame |
|---|---|
| Gait parameters At a single time point with multiple conditions including comfortable speed, fast speed, single-task, and dual-task. Temporospatials,Gait motion At a single time point with multiple conditions including comfortable speed, fast speed, single-task, and dual-task. Kinematics | — |
Countries
Thailand
Contacts
Public ContactSunee Bovonsunthonchai
Faculty of Physical Therapy, Mahidol University
Outcome results
None listed