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Efficacy of serial transcranial-focused ultrasound stimulation of human visual cortex on visual improvement: a randomized sham-controlled trial

Efficacy of serial transcranial-focused ultrasound stimulation of human visual cortex on visual improvement: a randomized sham-controlled trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250731003
Enrollment
60
Registered
2025-07-31
Start date
2025-08-15
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Visual impairment Visual impairment

Interventions

The intervention of interest in this study is visual cortex stimulation using tFUS with a neuronavigation system. Participants in the intervention group will receive the intervention monthly for 3-12
Brain stimulation,Sham Control

Sponsors

Faculty of Medicine Ramathibodi Hospital, Mahidol University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Adults; having unilateral or bilateral eye involvement, having lesions that cause visual impairment at the anterior visual pathway; brain MRI is available from routine clinical assessments; willing to participate in this study and sign an informed consent form.

Exclusion criteria

Exclusion criteria: Having been diagnosed with dementia, encephalopathy, or alteration of consciousness; attention deficit includes inattention (difficulty maintaining focus), hyperactivity (excessive movement inappropriate to the setting), and impulsivity (acting hastily without consideration), assessed through clinical neurological examinations; Having been prescribed the medications with a sedation effect such as benzodiazepine, high dose phenobarbital.

Design outcomes

Primary

MeasureTime frame
Visual acuity months Snellen chart

Secondary

MeasureTime frame
other perception months descriptive

Countries

Thailand

Contacts

Public ContactPanitha Jindahra

Faculty of Medicine, Ramathibodi Hospital, Mahidol University

panitha.jin@mahidol.ac.th022011386

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026