Patients with photoaging of the skin Facial Rejuvenation Microneedling bipolar radiofrequency Photoaging
Conditions
Interventions
Patients were treated with bipolar radiofrequency microneedling system. Test side was covered with hyaluronic acid, glutathione, ascorbic acid combined solution 10 mL. Control side was covered with st
Experimental Device,Experimental Device
Bipolar radiofrequency microneedling with test side was covered with hyaluronic acid, glutathione, ascorbic acid combined solution 10 mL,Bipolar radiofrequency microneedling with control side was cove
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. aged 30-60 years 2. Fitzpatrick Skin type III-V 3. were diagnosed with at least moderate photoaged skin (Glogau classification of photoaging) by dermatologist
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women 2. Volunteers with a history of platelet disorders, coagulation disorders, anemia, liver disease, cancer or autoimmune diseases 3. Volunteers with history of smoking or heavy alcohol consumption 4. Volunteers with facial dermatitis, wounds or skin infections 5. Volunteers with history of allergy to local anesthetics 6. Volunteers with a history of taking hormones, injectable contraceptives, or regular use of NSAIDs 7. Volunteers with a history of taking medications that affect blood coagulation, such as aspirin or anticoagulants 8. Volunteers who have taken anti-inflammatory or antiplatelet drugs within 72 hours prior to treatment 9. Volunteers with a history of facial lifting procedures, such as lifting devices or thread lifting, within 6 months prior to enrollment 10. Volunteers with a history of facial filler injections within 6 months prior to enrollment 11. Volunteers with a history of platelet-rich plasma (PRP) facial injections within 6 months prior to enrollment 12. Volunteers with a history of botulinum toxin facial injections within 6 months prior to enrollment 13. Volunteers with a history of collagen-stimulating facial lasers, such as picosecond laser, Erbium:YAG laser, Fractora, or eMatrix laser within 6 months prior to enrollment 14. Volunteers with a history of hypertrophic scars or keloids 15. Volunteers with a history of sex hormone use (topical, oral, injectable, or implant) within 6 months prior to enrollment 16. Volunteers diagnosed with psychiatric disorders by a psychiatrist 17. Volunteers who do not consent to facial photography for treatment evaluation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Textures by Antera Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Antera,Pigmentation by Antera Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Antera,Redness by Antera Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Antera | — |
Secondary
| Measure | Time frame |
|---|---|
| Sebum Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Sebumeter,Individual Typology Angle Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Colorimeter,Hydration Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Corneometer,Pigmentation Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Mexameter,R0 Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Cutometer,R2 Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Cutometer,Safety Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. Adverse event,Physician improvement scale Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. percent improvement,Patient Improvement scale Baseline, second treatment, third treatment, 2 weeks, 1 month, 2 months, 3 months and 6 months. percent improvement,Transepidermal water loss Baseline Tewameter,Pain score Baseline, second treatment, third treatment VAS | — |
Countries
Thailand
Contacts
Public ContactRungsima Wanitphakdeedecha
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed