Efficacy of unriped banana powder versus placebo in treatment of non- erosive reflux disease (NERD)

Efficacy of unriped banana powder versus placebo in treatment of non- erosive reflux disease (NERD), A multi center randomized controlled trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250730002

Enrollment

Registered

2025-07-30

Start date

2025-03-13

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Improvement of Symptoms in patient with non- erosive reflux disease Unriped banana powder , non -erosive reflux disease

Interventions

Uriped banana powder 2 tablets PO AC TID,Placebo drug 2 tablets PO AC TID

Active Comparator Drug,Placebo Comparator No treatment

Unriped banana powder,Placebo

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1 .patient age 18-80 years old 2. patient diagnosed GERD according to Montreal definition 3. patients who had done EGD and EGD not shown esophagitis 4.patient who received PPIs at least 4 wks before enrolled to this study 5. Patients consented to participate in the research

Exclusion criteria

Exclusion criteria: 1. patients with history of banana or banana components allergy or previous history of banana allergy ,such as abnormal Vital signs, low blood pressure, severe allergic reaction and respiratory distress 2.patients who have pathology from EGD 3. H. pylori infection detected 4.Patients who have acute gastrointestinal bleeding 5.patients who have Hb < 10 g/dl 6.Patient who have involuntary weight loss > 5% in 1 month or 10% in 6 months 7.patient who have history of esophageal cancer 8.patients who have jaundice (TB > 2 mg/dl) 9.Patients with CKD stage4 (eGFR < 30 ml/min/1.73 m2) 10.Patient who taking NSAIds or ASA or other anti platelets with in 4 wks 11. pregnant women or planing to pregnant or during breast feeding

Design outcomes

Primary

Measure	Time frame
NERD symptoms At day 0 of treatment , day 14 and day 28 RESQ-7 ,GERDQ	—

Secondary

Measure	Time frame
Side effects and quality of life GERD - HRQL at day of treatment and day 28 after intervention , side effects of treatment at day 14 and day 28 after treatment GERD -HRQL and patient reported outcomes using a questionnaire interview	—

Countries

Thailand

Contacts

Public Contactjakkrit promma

Phramongkutklao hospital

jukkrit_promma@hotmail.com027634297

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026