Fever and leukocytosis in adult patients without sepsis managed in the emergency department using ambulatory parenteral antibiotics Fever, Leukocytosis, Anti-Bacterial Agents, Ambulatory Care, Treatment Outcome, Leukocyte Count
Conditions
Interventions
Intravenous ceftriaxone for 1 day, then oral cefixime.,Intravenous ceftriaxone for 3 days, then oral cefixime.,Intravenous ceftriaxone plus oral doxycycline concurrently for 3 days, then continue oral
Treatment,Treatment,Treatment
Regimen A,Regimen B,Regimen C
Sponsors
Lampang Hospital, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Body temperature >37.8 C measured by infrared thermometer 2. White blood cell count >11,000 cells/mm3
Exclusion criteria
Exclusion criteria: 1. National early warning score (NEWS score) >5 2. Blood lactate >2.0 mmol/L 3. Hemodynamic instability 4. Known allergy to any of the antibiotic regimens under investigation 5. Identifiable source of infection in the emergency department
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| White blood cell reduction 3-5 days after initial treatment compare complete blood count by MINDRAY fully automated hematology analyzer | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical improvement 3-5 days after initial treatment Clinical sepsis assessed at follow-up by physician | — |
Countries
Thailand
Contacts
Public ContactWoraphat Tumporn
Department of Emergency Medicine, Lampang Hospital
Outcome results
None listed