Medication related osteonecrosis of the jaw Osteoporosis Medication related osteonecrosis of the jaw Antisorptive drug Biomarker Gingival crevicular fluid ELISA
Conditions
Interventions
Patients who have MRONJ stage 1-3
,Patients undergoing treatment with antiresorptive agents for more than 4 years without clinical or radiographic evidence of MRONJ
,Volunteers who have not received
Diagnostic,Diagnostic,Diagnostic
MRONJ stage,ADR group,Healthy
Sponsors
Oral surgery department
Eligibility
Sex/Gender
Female
Age
50 Years to 100 Years
Inclusion criteria
Inclusion criteria: Female subjects with age not less than 50 years old who meet one of these three criteria 1) History of antiresorptive therapy (bisphosphonates or denosumab) and diagnosed with MRONJ 2) Undergoing antiresorptive therapy for more than four years without MRONJ 3) No history of antiresorptive therapy and MRONJ
Exclusion criteria
Exclusion criteria: 1. Receiving antiresorptive agents due to other conditions such as bone cancer and bone metastatic conditions 2. Uncontrolled systemic diseases (diabetes milletus, hypertension) 3. Smoking habits 4. Current steroid use 5. Complete edentulism 6. History of radiation at head and neck area 7. Untreated periodontitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of cytokines At the examination date ELISA test | — |
Countries
Thailand
Contacts
Public ContactPakkanan Nateetaweewat
Faculty of dentistry, Chulalomgkorn University
Outcome results
None listed