Patient who had been diagnosed with melasma picosecond laser,melasma,exosome
Conditions
Interventions
1. Picosecond Laser Treatment
-A standardized Picosecond laser device will be used.
-Laser parameters such as wavelength, energy, spot size, and number of passes will be predefined and consistent acro
Picosecond laser and Exosome ,Picosecond laser and Placebo gel
Sponsors
None listed
Eligibility
Sex/Gender
Female
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed for melasma , symmetrical 2. Female, aged from 20-60 years old 3. Fitzpatrick skin type III-V 4. Duration of disease more than 1 year
Exclusion criteria
Exclusion criteria: Treatment with topical or systemic vitamin A and/or topical HQ in the past 3 months Chemical or microdermabrasion within the last 6 months Use of topical or systemic Alpha Hydroxyl Acid (AHA) products on the face in the last 1 month History of herpes simplex on the face History of poor wound healing or abnormal scarring Inevitable intense sun exposure Pregnant or lactating Having active inflammatory disease, infection or open wound at the treatment area History of premalignant or malignant lesion at the treatment site Undergoing hormonal therapy On oral tranquillizer or photosensitizing drugs Patients with psychiatric disorder Other causes of hyperpigmentation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pigmentation reduction and melasma severity assessment before ,1 month, 2 months, and 3 months after treatment. Modified Melasma Area and Severity Index (mMASI) | — |
Secondary
| Measure | Time frame |
|---|---|
| Pigmentation reduction and melasma severity assessment before ,1 month, 2 months, and 3 months after treatment. melanin index,Pigmentation reduction and melasma severity assessment 1 month, 2 months, and 3 months after treatment. Investigator's Global Assessment (IGA),Pigmentation reduction and melasma severity assessment 1 month, 2 months, and 3 months after treatment. Patient's Global Assessment (PGA),Safety and adverse event assessmen 1 month, 2 months, and 3 months after treatment. questionaire,Patient satisfaction scores 1 month, 2 months, and 3 months after treatment. questionaire | — |
Countries
Thailand
Contacts
Public ContactTawinun CHIMNAK
Dhurakitbundit university
Outcome results
None listed