Healthy condition Herbal tea, Mulberry leaves, Tomato, Working memory, Anti-aging
Conditions
Interventions
Placebo group, which received mulberry tea for 8 weeks, 20 volunteers.,Group receiving 1,050 mg/day of mulberry leaf tea mixed with tomato for 8 weeks, 20 volunteers.,Group receiving 2,100 mg/day of
Placebo,1,050 mg/day of mulberry leaf tea mixed with tomato ,2,100 mg/day of mulberry leaf tea mixed with tomato
Sponsors
Agricultural Research Development Agency (ARDA)
Eligibility
Sex/Gender
All
Age
35 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Healthy male and female volunteers aged 35-60 years 2) Able to communicate, read and write Thai
Exclusion criteria
Exclusion criteria: 1 Diagnosed with lung disease, asthma or allergies, cardiovascular disease, respiratory system disease, neurological disease or head injury, gout or high uric acid, diabetes, high blood fat, high blood pressure, kidney disease, liver disease, cancer, immune system disease , blood system disease, and diagnosed with psychiatric diseases such as anxiety or depression or schizophrenia or ADHD or autism or learning disorders 2 Have a history of drug abuse 3 Need to use any supplements or medications that affect the functioning of the nervous system as prescribed by the treating physician Before joining the project 4 Eating fermented food or yoghurt or probiotics more than 3 times a week 5 Exercising moderately strenuous more than or equal to 3 days a week 6 Taking any medication or other herbal medicines for at least 1 month before joining the project 7 Women receiving hormone therapy for menopause 8 Currently participating in other projects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain waves; EEG 0, 4, 8 weeks Event Related Potential (ERP) | — |
Secondary
| Measure | Time frame |
|---|---|
| Working memory 0, 4, 8 weeks Computerized battery test (CDR),Skin ageing changes 0, 4, 8 weeks ASL 100 Skin analyzer (Korea),Sleep quality test 0, 4, 8 weeks Pittsburgh Sleep Quality Index (PSQI),Anxiety status 0, 4, 8 weeks Beck Anxiety Inventory (BAI) and State Worrying Questionnaire (PSWQ),Lipid profile changes 0, 4, 8 weeks Hospital Laboratory,Cortisol level 0, 4, 8 weeks Hospital Laboratory,Mechanism of memory and neurotransmitter, and neuroplasticity 0, 4, 8 weeks Acetylcholinesterase, Monoamine oxidase (MAO), MAO-A, MAO-B, GABA transaminase (GABA-T), Brain Derived Nerve Growth Factor (BDNF), report by HHP&HP Laboratory,Mechanism related Oxidative stress 0, 4, 8 weeks MDA, SOD, Nrf2 by HHP&HP Laboratory | — |
Countries
Thailand
Contacts
Public ContactWipawee Thukhammee
Faculty of Medicine, Khon Kaen University
Outcome results
None listed