The primary health condition studied is Alzheimers disease. Alzheimer Disease Cognitive Dysfunction Gait Disorders, Neurologic Transcranial Direct Current Stimulation
Conditions
Interventions
cathodal electrodes at FP1, FZ, C3, and F7
Mode of administration: Non-invasive brain stimulation using HD-tDCS device
Setting: Administered in a clinical or research facility under supervision,Dose
HD-tDCS targeting the dorsolateral prefrontal cortex,HD-tDCS targeting the supplementary motor area,Sham HD-tDCS
Sponsors
MacKay Medical College
Eligibility
Sex/Gender
All
Age
60 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. Age 60 years or older 2. Able to walk independently for more than 10 meters without assistive devices 3. Diagnosis of probable Alzheimers disease based on the National Institute on Aging and Alzheimers Association (NIA-AA) criteria 4. Clinical Dementia Rating (CDR) score of 1 or higher 5. Able to follow basic instructions
Exclusion criteria
Exclusion criteria: 1. Dementia caused by other neurological or psychiatric conditions 2. Severe depression based on standardized assessment 3. Presence of additional neurological disorders 4. Presence of psychiatric disorders 5. Medical conditions that interfere with participation in physical or cognitive assessments 6. Presence of metallic implants, pacemakers, or other contraindications to brain stimulation or EEG 7. Inability to follow instructions or complete the intervention due to physical or communication limitations unrelated to AD 8. Concurrent participation in other interventional studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognition two times, two days Montreal cognitive assessment,cognition two times, two days Mini-Mental State Examination,executive function two times, two days Trial making test,attention two times, two days Digital symbol modality test,episode memory two times, two days California verbal language test-short form,visuospatial perofrmance two times, two days Judgment of line orientation,naming two times, two days Boston naming test,depression two times, two days Geriatric depression scale | — |
Secondary
| Measure | Time frame |
|---|---|
| physical function two times, two days Timed Up and Go test,physical function two times, two days Short Physical Performance Battery,dual-task performance two times, two days cognitive dual task,dual-task performance two times, two days motor dual task,plasma biomarker two times, two days Brain-Derived Neurotrophic Factor,plasma biomarker two times, two days amyloid protein,plasma biomarker two times, two days tau protein,plasma biomarker two times, two days neurofilament light peptide | — |
Countries
Taiwan
Contacts
Public ContactFangYu Cheng
MacKay Medical College
Outcome results
None listed