Researchers developed a novel topical product containing A. paniculata extract for easier application to burn wounds
Conditions
Interventions
Four test sites of upper arm (right anterior, right posterior, left anterior, and left posterior upper arms) were identified on each participant. Four creams were randomly applied, one to each site :c
Cream base,Topical preparation containing 5% A. paniculata extraction,silver sulfadiazine,Topical preparation containing 10% A. paniculata extraction
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: healthy volunteers aged 18 to 65 years and the ability to follow study instructions
Exclusion criteria
Exclusion criteria: known pregnancy or breastfeeding, Andrographis allergy, bleeding disorders, use of anticoagulants or antiplatelets, drugs affecting cytochrome P450, immunosuppressive medications, or the presence of wounds at the test site.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Allergic reaction assessment following day 3 and 7 at 7 days s after end of the intervention Friedman test to assess differences among groups, while changes in allergic reactions over time were analyzed using the Wilcoxon Signed Ranks Test | — |
Secondary
| Measure | Time frame |
|---|---|
| level of iching at 7 days after end of the intervention Friedman test to assess differences among groups, while changes in allergic reactions over time were analyzed using the Wilcoxon Signed Ranks Test,User Satisfaction after end of the intervention ANOVA or pair T-test | — |
Countries
Thailand
Contacts
Public ContactSuphat Watthanathiranon
Division of surgery, Faculty of Medicine Siriraj Hospital
Outcome results
None listed