Vitamin D Inadequacy in Postmenopausal Osteoporosis Vitamin D insufficiency, vitamin D deficiency, Postmenopausal Osteoporosis, split dose, single dose
Conditions
Interventions
Separate split dose into 2 subgruops
For below 20 ng/ml
- Monday : 1 Active calciferol + 2 Placebo
- Wednesday: 1 Active calciferol
- Friday: 1 Active calciferol
For 20-30 ng/ml
- Monday: 1 Active ca
Experimental Drug,Experimental Drug
Split dose of vitamin D,Single dose of vitamin D
Sponsors
MAHAVAJIRALONGKORN FOUNDATION
Eligibility
Sex/Gender
Female
Age
45 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis: osteoporosis according to Thai guideline 2. Post-menopausal women 3. age between 45-90
Exclusion criteria
Exclusion criteria: 1.Chronic renal failure 2. Chronic liver failure 3. Medical problems affect Vitamin D absorption and metabolism 4. Abnormal calcium or parathyroid level at start Pregnancy Receiving vitamin D >400 IU/day in other formular Secondary osteoporosis Reject to sign the informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vitamin D change 4, 12 weeks Serum 25(OH)D | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of vitamin D adequacy after treatment 4,12 weeks Proportion of Vitamin D adequacy,Calcium change 4,12 weeks Difference of Calcium level,Phosphate change 4,12 weeks Difference of Phosphate level,PTH change 4, 12 weeks Difference of Phosphate level | — |
Countries
Thailand
Contacts
Public ContactPhatsawit Kunsuwan
Department of Orthopaedics, Phramongkutklao Hospital
Outcome results
None listed