Study of low-dose dexmedetomidine to reduce shivering after spinal anesthesia in knee replacement surgery

Effectiveness of Low-dose Intravenous Dexmedetomidine Prevent Shivering in Total Knee Arthroplasty under Spinal Anesthesia: A Randomized Controlled Trial

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250712001

Enrollment

Registered

2025-07-12

Start date

2025-03-18

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The patients who are going to total knee arthroplasty under spinal anesthesia. Dexmedetomidine, Prevent shivering, Spinal anesthesia

Interventions

The intervention group receives dexmedetomidine 10 micrograms diluted in 10 milliliter of normal saline administered intravenous over 10 minutes after spinal anesthesia.,The control group receives 10

Experimental Drug,No Intervention No treatment

Dexmedetomidine,Control

Eligibility

Sex/Gender

All

Age

55 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing total knee arthroplasty under spinal anesthesia at Samut Prakan Hospital 2. Age between 55-85 year-old 3. ASA physical status I-II

Exclusion criteria

Exclusion criteria: 1. Patients who have history of heart disease, respiratory disease, neuromuscular disease. 2. Patients who have BMI more than 30 kg/m2 3. Patients who have body temperature less than 35 or more than 38 degree celsius

Design outcomes

Primary

Measure	Time frame
Preventing Shivering From Operative room to Recovery room Shivering Grading (0 is no shivering, 1 is mild fasciculation of the face or neck, 2 is visible tremor involving more than one muscle group, 3 is gross muscular activity involving the entire body)	—

Secondary

Measure	Time frame
Bradycardia From Operative room to Recovery room Heart rate less than 20% of heart rate baseline of the patient or less than 60 beats per minute,Tachycardia From Operative room to Recovery room Heart rate more than 20% of heart rate baseline of the patient,Hypertension From Operative room to Recovery room Blood pressure more than 20% of blood pressure baseline of the patient,Hypotension From Operative room to Recovery room Blood pressure less than 20% of blood pressure baseline of the patient,Nausea From Operative room to Recovery room Present or not,Vomit From Operative room to Recovery room Present or not,dizziness From Operative room to Recovery room Present or not,Dry mouth From Operative room to Recovery room Present or not,Itching From Operative room to Recovery room Present or not,Hallucination From Operative room to Recovery room Present or not	—

Measure

Time frame

Bradycardia From Operative room to Recovery room Heart rate less than 20% of heart rate baseline of the patient or less than 60 beats per minute,Tachycardia From Operative room to Recovery room Heart rate more than 20% of heart rate baseline of the patient,Hypertension From Operative room to Recovery room Blood pressure more than 20% of blood pressure baseline of the patient,Hypotension From Operative room to Recovery room Blood pressure less than 20% of blood pressure baseline of the patient,Nausea From Operative room to Recovery room Present or not,Vomit From Operative room to Recovery room Present or not,dizziness From Operative room to Recovery room Present or not,Dry mouth From Operative room to Recovery room Present or not,Itching From Operative room to Recovery room Present or not,Hallucination From Operative room to Recovery room Present or not

—

Countries

Thailand

Contacts

Public ContactNutnicha Thongthaweeporn

Samut Prakran Hospital

nutnichathong@gmail.com66923654115

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026