Chronic rhinosinusitis with nasal polyps Chronic rhinosinusitis, nasal polyps, endoscopic sinus surgery, polyp recurrence, antibiotic nasal irrigation
Conditions
Interventions
Levofloxacin (500 mg) 0.25 tablet crushed and mixed with 0.9% normal saline 250 ml and pulmicort (0.5 mg/2ml) 1 respule and used 125 ml of solution for irrigation each nostril 2 times per day,Doxycycl
Active Comparator Drug,Active Comparator Drug
Levofloxacin,Doxycycline
Sponsors
Faculty of medicine, Khon Kaen university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-65 years 2. Patients diagnosed with chronic rhinosinusitis with bilateral nasal polyps, excluding cases of recurrent nasal polyps after previous surgery 3. Patients scheduled for bilateral full house Functional Endoscopic Sinus Surgery (FESS)
Exclusion criteria
Exclusion criteria: 1. Patients with a history of allergy to fluoroquinolone or tetracycline antibiotics 2. Patients diagnosed with cystic fibrosis or other mucociliary disorders, as indicated by involvement of other organs 3. Patients with immunodeficiency 4. Patients currently receiving treatment with biological agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence of nasal polyps post-surgery 1 month and 3 months Lund-Kennedy nasal endoscopic score (only nasal polyp parameter) | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-surgery nasal symptoms 1 month and 3 months Thai SNOT-22 score,Lund-Kennedy nasal endoscopic score Post-surgery 1 month and 3 months Lund-Kennedy nasal endoscopic score (Total score),Bacteria culture results from nasal cavity and sinus 1 month Sinonasal secretion or tissue for aerobic bacteria culture,Complications and side effects from using antibiotic nasal irrigation 1 month and 3 months Patient report | — |
Countries
Thailand
Contacts
Public ContactAmika Chongvivatsuntorn
Khon Kaen university
Outcome results
None listed