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EFFECTIVENESS OF PLATELET-RICH PLASMA ALONG WITH PHYSIOTHERAPY ON BIOMARKERS, SOFT-TISSUE MORPHOLOGY AND FUNCTION FOR SHOULDER ADHESIVE CAPSULITIS

Effectiveness of Platelet-Rich Plasma along with Physiotherapy on Biomarkers, Soft-tissue Morphology and Function for Shoulder Adhesive Capsulitis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250709004
Enrollment
60
Registered
2025-07-09
Start date
2025-08-12
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Shoulder Adhesive Capsulitis Adhesive Capsulitis Capsulitis, Adhesive Frozen Shoulder Shoulder, Frozen Adhesive Capsulitis of the Shoulder Shoulder Adhesive Capsulitis

Interventions

PRP therapy: A single dosage of 4 mL of PRP mixed with 1 mL of 2% lidocaine in a 22-gauge spinal needle under aseptic conditions will be inserted in the affected joint. Proprioceptive Neuromuscular
IR (arm at side), Theraband exercise Treatment session: 30 minutes of each session
4 times a week for up to 6 weeks.,Sham PRP therapy: A single dosage of 1 mL of 2% lidocaine in a 22-gauge spinal needle under aseptic conditions will be inserted in the affected joint. Proprioceptiv
IR (arm at side), Theraband exercise Treatment session: 30 minutes of each session
4 times a week for up to 6 weeks.
Experimental Other,Sham Comparator Other
Platelet Rich Plasma (PRP) with Physiotherapy ,Sham Platelet Rich Plasma (PRP) with Physiotherapy

Sponsors

Department of Physiotherapy and Rehabilitation, Jashore University of Science and Technology, Jashore 7408, Bangladesh.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Individuals aged 20 to 65 years 2. Who have experienced shoulder pain for less than three months, 3. Pain aggravated by shoulder movement and 4. Notable passive range of motion limitations in more than one plane.

Exclusion criteria

Exclusion criteria: 1. Bilateral adhesive capsulitis. 2. Prior glenohumeral joint injection within the last six months. 3. Previous medication use or surgical intervention for adhesive capsulitis, or manipulation under anesthesia. 4. Participants having present with neurologic impairments affecting shoulder function during activities of daily living. 5. Confirmed brachial plexopathy via nerve conduction study. 6. Pain or pathology in adjacent joints (cervical spine, elbow, wrist, or hand), or 7. Any contraindications to injection therapy such as local cellulitis, septic arthritis, or acute fracture

Design outcomes

Primary

MeasureTime frame
Pressure pain threshold Baseline and after completion of intervention Pressure pain algometer,Cell count of the RBC, WBC and T cell Baseline and after completion of intervention Microscopic examination of aspirated synovial fluid of affected shoulder joint,Soft tissue morphology (length and diameter) of supraspinatus, infraspinatus, biceps and pectoralis major muscles Baseline and after completion of intervention Musculoskeletal Ultrasound (MSK-USG)

Secondary

MeasureTime frame
Functional activity of shoulder joint Baseline and after completion of intervention Shoulder Pain and Disability Index (SPADI)

Countries

Bangladesh

Contacts

Public ContactDr. K M Amran Hossain

Lecturer, Department of Physiotherapy and Rehabilitation

kma.hossain@just.edu.bd01735661492

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026