Healthy volunteers with overweight or obesity (BMI greater than or equal 25 kg per m2) Garcinia pedunculata, Hydroxycitric acid (HCA), obesity, weight control, herbal medicine
Conditions
Interventions
Consuming ready-to-eat jelly without Garcinia extract, 2 sachets/day (50 g/sachet) for 8 weeks,Consuming ready-to-eat jelly with Garcinia extract, 2 sachets/day (50 g/sachet) for 8 weeks
placebo ,Test product
Sponsors
Thailand Science Research and Innovation (TSRI)
Eligibility
Sex/Gender
All
Age
20 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Healthy female or male participants aged between 20-59 years 2. Able to listen, speak, and read the Thai language 3. Having a BMI greater than or equal to 25 kilograms per square meter 4. Willing to voluntarily participate in the research and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Have a history of allergy to Garcinia extract or any ingredients in the product, such as gelling agents, xylitol, or sorbitol 2. Have a history of taking medications that affect blood sugar or lipid levels 3. Have a history of taking weight control drugs or dietary supplements such as laxatives within the past two weeks 4. Have a history of taking any other Garcinia-containing products within the past two weeks 5. Have a history of hematologic disorders such as thrombocytopenia or abnormal bleeding 6. Diagnosed by a physician with diabetes ischemic heart disease heart failure or thyroid disorders 7. Having peptic ulcer disease or irritable bowel syndrome 8. Liver function test results showing aspartate aminotransferase or alanine aminotransferase more than 2 times the upper limit of normal 9. Kidney function test showing creatinine levels more than 1.5 times the upper limit of normal 10. Abnormal urine or stool test results 11. Diagnosed by a physician with severe psychiatric disorders 12. Have a history of receiving obesity treatment within the past three months 13. Currently pregnant or breastfeeding 14. Have a history of undergoing major surgery within the past 1 year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body mass index Week 0, 4, 8 Body weight and height measured using digital scale and stadiometer,Body weight Week 0, 4, 8 measured using digital scale and stadiometer | — |
Secondary
| Measure | Time frame |
|---|---|
| Body fat percentage Week 0, 4, 8 Bioelectrical impedance analysis,Waist circumference Week 0, 4, 8 Measured using flexible non-stretchable tape,Lipid profiles Week 0, 4, 8 Enzymatic colorimetric method,Serum leptin concentration Week 0, 4, 8 Measured using ELISA assay,Participant satisfaction Week8 Questionnaire-based evaluation | — |
Countries
Thailand
Contacts
Public ContactKrongkarn Choothip
Faculty of Medical Science, Naresuan University, Phitsanulok
Outcome results
None listed