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Efficacy of acetylcysteine nebulizer for improvement of symptoms in bronchiectasis patients: a randomized controlled trial

Efficacy of acetylcysteine nebulizer for improvement of symptoms in bronchiectasis patients: a randomized controlled trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250707006
Enrollment
36
Registered
2025-07-07
Start date
2025-04-08
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiectasis patients have a large amount of sputum and secretions. Acetylcysteiene, nebulizer, bronchiectasis, normal saline

Interventions

acetylcysteine nebulizer (300mg/3ml) 3 ml bid,normal saline nebulizer 3 ml bid
Experimental Drug,Experimental Drug
acetylcysteine nebulizer,normal saline nebulizer

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 years or older. 2. Diagnosed with bronchiectasis by a physician, based on symptoms and chest imaging (x-ray or CT scan). 3. Willing to participate by signing consent.

Exclusion criteria

Exclusion criteria: 1. Patients who have not quit smoking or have quit smoking for less than 6 months. 2. Patients diagnosed with cystic fibrosis. 3. Patients with pulmonary function test results showing FEV1 lower than 30%. 4. Pregnant patients. 5. Participants who decline or wish to withdraw from the study.

Design outcomes

Primary

MeasureTime frame
sputum over 2 weeks sputum volume

Secondary

MeasureTime frame
cough symptoms, fatigue, and quality of life through assessments over 2 weeks St. George's Respiratory Questionnaire (SGRQ), modified Medical Research Council (mMRC) dyspnea scale, COPD Assessment Test (CAT), and the Thai version of the Leicester Cough Questionnaire

Countries

Thailand

Contacts

Public ContactSupiya Kijlertsuphasri

Faculty of Medicine Ramathibodi Hospital

mcsupiya@gmail.com0818238735

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026