Cardiac arrest at the emergency department cardiac arrest emergency department epinephrine epinephrine administration interval
Conditions
Interventions
Patients meeting enrollment criteria will be randomized to the shorter EAI (3-min interval) or longer EAI (5-min interval) in a ratio of 1:1. Due to the narrow time window of the study intervention, r
Experimental Drug,Active Comparator Drug
Shorter EAI,Longer EAI
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Greater than or equal to 18 years old AND (2) Documented cardiac arrest in the ED defined by as the absence of cardiac mechanical activity, confirmed by a lack of clinical evidence of circulation AND (3) Attempted resuscitation by ED personnel, defined as external shock delivery or chest compressions.
Exclusion criteria
Exclusion criteria: (1) Unable to administer epinephrine within 2 minutes after cardiac arrest (2) Known pregnancy (3) Known prisoners (4) Previous enrollment into the EPINEP trial (5) Non-Thai and non-English speaking (6) Had a Do-Not-Attempt-Resuscitation (DNAR) order
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of survival to hospital discharge At hospital discharge Yes/No | — |
Secondary
| Measure | Time frame |
|---|---|
| Return of spontaneous circulation (ROSC) After attempted resuscitation Yes/No,Neurologically intact survival at hospital discharge status At hospital discharge Favorable/Unfavorable | — |
Countries
Thailand
Contacts
Public ContactWachira Wongtanasarasin
Faculty of Medicine, Chiang Mai University
Outcome results
None listed