Intraoperative blood loss in patient undergoing bimaxillary orthognathic surgery Reducing intraoperative blood loss Tranexamic acid Orthognathic surgery Bimaxillary surgery
Conditions
Interventions
Thirty minutes prior to surgery, patients in Group 1 received 2 grams of tranexamic acid in oral form, administered as 8 capsules of 250 mg each. After induction of general anesthesia, these patients
Experimental Drug,Active Comparator Drug
Oral tranexamic acid,IV tranexamic acid
Sponsors
Satha Lerwiwattaworn
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologist (ASA): class I,II 2. Patients undergoing segmented and non-segmented Bimaxillary surgery without craniofacial syndromes such as cleft 3.Weight : 45-75 kg
Exclusion criteria
Exclusion criteria: 1. History of allergy to any medications relevant to the study, such as tranexamic acid, propofol, succinylcholine, or cisatracurium. 2. Presence of coagulation disorders (coagulopathy), either from medical history or abnormal laboratory findings such as platelet count, prothrombin time (PT), partial thromboplastin time (PTT), or bleeding time. 3. History of thromboembolic events, including deep vein thrombosis (DVT). 4. Uncontrolled hypertension. 5. Presence of cardiovascular diseases. 6. Uncontrolled diabetes mellitus. 7. Known liver or kidney dysfunction. 8. Current use of NSAIDs, antiplatelet agents, anticoagulants, or anticonvulsants. 9. Pregnant individuals or those experiencing abnormally heavy menstrual bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total intraoperative blood loss end of surgery ml | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in Hb concentration end of surgery g/dL,Calculated blood loss end of surgery ml,Operative time end of surgery hr,Blood transfusion discharged from hospital unit,ml,Adverse events discharged from hospital events | — |
Countries
Thailand
Contacts
Public ContactSatha Lerwiwattaworn
Faculty of dentistry , Prince of Songkhla university
Outcome results
None listed