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Comparison the effects of Articaine and Lidocaine Anesthetics on Blood pressure after maxillary infiltration technique: A Double Blind Randomized Technique

comparison the effects of Articaine and Lidocaine Anesthetics on Blood pressure after maxillary infiltration technique: A Double Blind Randomized Technique

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250625012
Enrollment
160
Registered
2025-06-25
Start date
2024-01-08
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood pressure and heart rate changes during dental anesthesia in healthy individuals (ASA I) Lidocaine, Articaine, Local Anesthesia, Epinephrine, Blood Pressure, Heart Rate, Root Canal Therapy, Hemodynamics, Dental Infiltration Anesthesia, Randomized Controlled Trial

Interventions

.8 mL of 2% lidocaine with 1:80,000 epinephrine (Lignospan Special) was administered via maxillary buccal infiltration using a 27-gauge short needle over 40 seconds by a single experienced operator. T
Active Comparator Drug,Experimental Drug
2% Lidocaine with 1:80,000 Epinephrine,4% Articaine with 1:100,000 epinephrine

Sponsors

Fatima Jinnah Dental College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18 to 60 years ASA I (healthy individuals with no systemic disease) Scheduled for maxillary root canal treatment requiring buccal infiltration anesthesia Low dental anxiety (Modified Corah's Dental Anxiety Scale score 1 or 2) No known allergies to amide-type local anesthetics Non-smokers Not pregnant

Exclusion criteria

Exclusion criteria: ASA II or higher History of hypertension or cardiovascular disease Use of medications affecting cardiovascular or nervous system function Allergy to amide-type local anesthetics Modified Corah's Dental Anxiety Scale score ( 3 and higher) Smokers Failure to achieve adequate anesthesia with a single injection (requiring supplemental anesthesia)

Design outcomes

Primary

MeasureTime frame
Blood pressure before and 10 minutes after injection manual sphygmomanometer before and 10 minutes after injection

Secondary

MeasureTime frame
Heart Rate before and 10 min after injection pulse oximeter

Countries

Pakistan

Contacts

Public ContactZainab Islam

Fatima Jinnah Dental College

zainabbeg@ymail.com03323154724

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026