Continuous renal replacement therapy Critically ill patients with acute kidney injury Continuous renal replacement therapy Critically ill patients Acute kidney injury
Conditions
Interventions
CRRT at dose of 20-25 ml/kg/h,CRRT at dose of 10-15 ml/kg/h
Active Comparator Drug,Active Comparator Drug
Sponsors
No
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Critically ill patients with acute kidney injury who require CRRT in medical or surgical intensive care unit and have received CRRT for more than 48 hours, along with the following criteria: a. pH greater than or equal to 7.25 b. Serum potassium less than or equal to 6 mmol/L c. BUN less than or equal to 100 mg/dL 2. Aged greater than or equal to 18 years.
Exclusion criteria
Exclusion criteria: 1. Chronic kidney disease stage 5 2. Pregnancy 3. Patients with history of allergic reaction to filter used for renal replacement therapy 4. Patients who receive intermittent hemodialysis, sustained low-efficiency daily dialysis, or peritoneal dialysis 5. Patients anticipated to have a life expectancy of less than 48 hours 6. Terminally ill patients or patient refuse to treatment 7. Require standard or high dose CRRT after initiate CRRT more than 48 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal replacement therapy free-day Day 30 post-enrollment Renal replacement therapy free-day at day 30,Renal replacement therapy dependence Day 30 post-enrollment Renal replacement therapy dependence at day 30 | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival rate Day 30 post-enrollment Survival rate at day 30,Rate of renal recovery Day 30 post-enrollment Rate of renal recovery at day 30,Major Adverse Kidney Event at day 30 (MAKE 30) Day 30 post-enrollment Major Adverse Kidney Event at day 30 (MAKE 30),Vasopressor-free days Day 30 post-enrollment Vasopressor-free days at day 30,Ventilator-free days Day 30 post-enrollment Ventilator-free days at day 30,ICU length of stay Until ICU discharge ICU length of stay,ICU mortality Day 30 post-enrollment ICU mortality,Hospital mortality Day 30 post-enrollment Hospital mortality,Hospital length of stay Until hospital discharge Hospital length of stay,Efficacy of metabolic control OD until day 3 Serum electrolytes levels,Adverse events Until day 30 post-enrollment Severe metabolic imbalance | — |
Countries
Thailand
Contacts
Public ContactThummaporn Naorungroj
Division of Critical Care, Department of Medicine, Siriraj Hospital, Mahidol University
Outcome results
None listed