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Effectiveness of Parasternal Block for Postoperative Analgesia in Patients Undergoing Cardiac Surgery via Median Sternotomy: A Randomized Controlled Trial

Effectiveness of Parasternal Block for Postoperative Analgesia in Patients Undergoing Cardiac Surgery via Median Sternotomy: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250622001
Enrollment
70
Registered
2025-06-22
Start date
2025-07-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain in cardiac surgery Postoperative pain in cardiac surgery, parasternal block

Interventions

Parasternal block at 2nd/3rd and 4th/5th bilaterally, 0.5% Ropivacaine 5 ml each injection site. Intraoperative intravenous fentanyl adjusted by hemodynamic responses. Postoperative PCA fentanyl 10 mc
Experimental Procedure/Surgery,No Intervention No treatment
parasternal block,control

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 18 - 65 years old undergoing cardiac surgery with median sternotomy at King Chulalongkorn Memorial Hospital, 2. Able to provide informed consent independently, 3. ASA (American Society of Anesthesiologists) class 1-3, 4. BMI 18-35 Kg/m2, 5. Extubation must be performed within 6 hours postoperatively

Exclusion criteria

Exclusion criteria: 1. Resternotomy, 2. Contraindication for parasternal block such as infection at parasternal area, preexisting coagulopathy, local anesthetic drugs allergy, 3. left ventricular ejection fraction below 30%, 4. intra aortic balloon pump or ECMO insertion, 5. non cooperate patients such as severe dementia, mental retard, 6. susceptibility for local anesthetic toxicity such as BMI under 18 Kg per m2, chronic liver disease, serum albumin level below 2.8 g per dL, 7. estimated GFR below 45 ml per min per 1.73m2, 8. chronic pain using daily opioids more than 3 months or morphine dose over than 60 mg per day more than 1 month, 9. diagnosed neuropathic pain or using gabapentinoid or tricyclic antidepressant, 10. reoperation within 24 hours

Design outcomes

Primary

MeasureTime frame
total fentanyl consumption intraoperative to 24 hours postoperative 24 hours postoperative microgram

Secondary

MeasureTime frame
Pain score 0, 4, 8, 12, 24 hours postoperative numeric rating scale,time to extubate extubation minutes,ICU stay discharge from ICU hours,incidence of opioid side effects 24 hours postoperative events,incidence of parasternal block complication 24 hours postoperative events,incidence of sternal/rib fracture 24 hours postoperative events,incidence of neuropathic pain 4, 8, 12 weeks postoperative events

Countries

Thailand

Contacts

Public ContactMutita Chaichalothorn

King Chulalongkorn Memorial Hospital

mutita.cha@chula.md0894426490

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026