Patients with facial skin laxity. facial skin laxity, Calcium Hydroxylapatite, CaHA, rejuvenation
Conditions
Interventions
Patients were injected with hyaluronic acid with 0.01% Calcium Hydroxylapatite at face and neck for total 5 ml once. Then they were instructed to follow up at immediate, 1 month after 1st treatment, 1
Experimental Drug
hyaluronic acid with 0.01% Calcium Hydroxylapatite injection
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 20-60 years 2. Patients with early-stage photoaging, characterized by one or more of the following: uneven skin tone, fine lines, mild wrinkles, dryness, or mild skin laxity in the facial or neck areas.
Exclusion criteria
Exclusion criteria: 1. Patients who are pregnant, lactating, and breastfeeding 2. Patients with a history of medical conditions such as abnormal platelet counts, blood clotting disorders, anemia, liver disease, cancer, or autoimmune disorders. 3. Patients who smoke or heavy alcohol consumption (14 drinks/week). 4. Patients with other skin diseases, or having infection at the area of face 5. Patients with history of local anasthesia allergy 6. Patients with a history of taking hormones or oral contraceptives, or those who regularly take NSAIDs (nonsteroidal anti-inflammatory drugs). 7. Patients with a history of taking medications that affect blood clotting, such as aspirin and anticoagulants. 8. Patients who have undergone facial lifting procedures, such as non-surgical lifting tools or thread lifting, within the 6 months. 9. Patients who have received dermal filler injections in the facial area within the 6 months. 10. Patients who have received platelet-rich plasma (PRP) injections in the facial area within the 6 months. 11. Patients who have received botulinum toxin injections in the facial area within the 6 months. 12. Patients who have undergone collagen-stimulating laser treatments in the facial area, such as Picosecond laser, Erbium: YAG laser, Fractora, or Laser E matrix, within the 6 months. 13. Patients with hypertrophic scar or keloid 14. Patients diagnosed with any mental health disorder by a psychiatrist. 15. Patients who do not consent to having photographs taken for the purpose of evaluating the treatment outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volume analysis Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. Quantificare,Volume analysis Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. Vectra H2 | — |
Secondary
| Measure | Time frame |
|---|---|
| Melanin and erythema index Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. mexameter,Skin elasticity Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. Cutometer,Skin hydration Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. corneometer,ITA Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. colorimeter,Sebum Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. sebum meter,Physician improvement scale 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. Quartile scale, Patient improvement scale 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. Quartile scale,Safety Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1, 3, 6, 9 and 12 months after complete the treatment. Adverse event | — |
Countries
Thailand
Contacts
Public ContactRungsima Wanitphakdeedecha
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed