Natural vs. Synthetic Desensitizers: A Randomized Controlled Trial Comparing the Efficacy of Java Tea and Little Ironweed Herbal Toothpaste with Potassium Nitrate Toothpaste in Managing Dentin Hypersensitivity

Clinical Study of Developed Herbal Desensitizing Toothpaste form Java Tea and Little Ironweed

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250616012

Enrollment

Registered

2025-06-16

Start date

2020-08-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tooth sensitivity Herbal product Java Tea Little Ironweed Orthosiphon aristatus Vernonia cinerea anti-sensitivity toothpaste dentin hypersensitivity

Interventions

Toothpaste containing Java Tea and Little Ironweed extract only,Toothpaste containing Java Tea and Little Ironweed extract with 0.7% potassium nitrate,Toothpaste containing 5% potassium nitrate and 0.

Experimental Drug,Active Comparator Drug,Active Comparator Drug

S1,S2,S3

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. The teeth that exhibited gingival recession with exposed root dentin

Exclusion criteria

Exclusion criteria: 1. The teeth that have dental caries or non-carious tooth surface loss requiring restorative intervention. 2. A patient who has undergone scaling and root planing within the past 30 days. 3. A Patient who has undergone tooth whitening within the past 90 days. 4. A Patient who has undergone orthodontic treatment within the past 90 days. 5. A Patient who has undergone dental surgery involving the target tooth within the past 90 days. 6. A Patient who has undergone the use of painkillers, anti-sensitizing agents, or alternative anti-sensitizing tooth-pastes before and during the study.

Design outcomes

Primary

Measure	Time frame
Tooth sensitivity Baseline VAS score from tactile stimulus,Tooth sensitivity 2 weeks VAS score from tactile stimulus,Tooth sensitivity 4 weeks VAS score from tactile stimulus	—

Secondary

Measure	Time frame
Tooth sensitivity Baseline VAS score from air stimulus,Tooth sensitivity 2 weeks VAS score from air stimulus,Tooth sensitivity 4 weeks VAS score from air stimulus	—

Countries

Thailand

Contacts

Public ContactVittawin Dechosilpa

university lecturer

vittawin@rsu.ac.th027916000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026