Severe Malaria Infection and Target Organ Injury

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20250615002

Enrollment

200

Registered

2025-06-15

Start date

2024-11-18

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

We conducted a retrospective cohort study of adult (from 18 years old) patients admitted with microscopy-confirmed P. vivax mono-infection. Plasmodium vivax, acute kidney injury, KDIGO, NGAL, KIM-1

Interventions

Patients admitted with microscopy-confirmed P. vivax mono-infection with severe malaria.,Patients admitted with microscopy-confirmed P. vivax mono-infection with non-severe malaria.

Diagnostic,Diagnostic

Study Group,Control Group

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients admitted with microscopy-confirmed P. vivax mono-infection.

Exclusion criteria

Exclusion criteria: Symptoms suggestive of any form of co-infection, Underlying compromising conditions such as recent trauma, HIV/AIDS, active malignancy, autoimmune diseases and long-term immunosuppressant use.

Design outcomes

Primary

Measure	Time frame
The prevalence of AKI in with P. vivax mono-infection 48 hours Using the modern KDIGO criteria.,Clinical predictors of acute kidney injury At enrollment A multivariable logistic regression model	—

Secondary

Measure	Time frame
Urinary NGAL level At enrollment Quantitative test (ng/mL),Urinary KIM-1 At enrollment Quantitative test (ng/mL)	—

Countries

Thailand

Contacts

Public ContactWiwat Chancharoenthana

Mahidol University

wiwat.cha@mahidol.ac.th023549168

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026