Hypovitaminosis D in pregnancy and associated maternal and neonatal complications such as pre-eclampsia, gestational diabetes, preterm birth, and low birth weight. Vitamin D Supplement Hypovitaminosis D Vitamin D insufficiency Vitamin D deficiency
Conditions
Interventions
Vitamin D2 20,000 IU orally once monthly
From gestational age 12 to 20 weeks until delivery,Vitamin D2 40,000 IU orally once monthly
From gestational age 12 to 20 weeks until delivery,Vitamin D2 60,00
Experimental Drug,Experimental Drug,Experimental Drug
Vitamin D 20000 IU per month,Vitamin D 40000 IU per month,Vitamin D 60000 IU per month
Sponsors
Rajavithi hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1 Singleton pregnancy 2 Aged between 20 to 5 years 3 Gestational age between 12 to20 weeks, confirmed by ultrasound in the first or second trimester. 4 Low blood vitamin D levels (25(OH)D below 30 ng/mL) 5 Able to communicate and understand Thai well to comprehend research explanations and personally sign consent forms. 6 Willing to participate in the research
Exclusion criteria
Exclusion criteria: 1 Pre-existing diabetes (diabetes diagnosed before pregnancy) 2 History of gestational diabetes 3 Kidney disease, liver disease, or conditions affecting vitamin D metabolism such as 4 malabsorption syndromes or genetic disorders related to vitamin D metabolism. 5 Autoimmune diseases like SLE (Systemic Lupus Erythematosus) or Multiple Sclerosis. 6 Hyperparathyroidism or high blood calcium levels. 7 History of using vitamin D supplements prior to the study. 8 Unable to follow up for the second vitamin D level measurement. 9 Hypertension (high blood pressure). 10 History of pre-eclampsia. 11 History of taking calcium supplements containing vitamin D.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| maternal serum 25(OH)D level during the third trimester ng/mL | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal outcomes during the third trimester GDM, preeclampsia, serum calcium/phosphate,Neonatal outcomes at delivery preterm birth, birth weight, Apgar score, cord blood vitamin D,Adverse effects from vitamin D supplementation during the third trimester any symptoms | — |
Countries
Thailand
Contacts
Public ContactDennopporn Sudjai
Rajavithi hospital
Outcome results
None listed