Functional Dyspepsia Functional Dyspepsia Amitriptyline Trifluoperazine Neuromodulator Dyspepsia DGBI Disorders of Gut Brain Interaction ROME IV Tricyclic antidepressant Antipsychotic Phenothiazine
Conditions
Interventions
Patients will get Tablet Amitriptyline 10 milligrams daily at night along with standard first line treatment,Patients will get Tablet Trifluoperazine 1 milligrams twice daily along with standard first
Amitriptyline,Trifluoperazine,Standard first line treatment only
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 years or more 2. Patients with FD diagnosed according to ROME IV criteria 3. Patients who are willing to sign informed written consent
Exclusion criteria
Exclusion criteria: 1.Structural lesion in Upper GI endoscopy and/or positive CLO test 2.Patients scoring 1 or 2 on the 5-point Likert scale for all four dyspepsia symptoms 3.History of malignancy, significant liver and biliary tract disease, hypertension, diabetes mellitus, chronic kidney disease, thyroid disorder, major psychiatric disorders 4.Previous history of gastrointestinal surgery 5.Patients those have to take any drug for other medical condition that may cause dyspepsia, can interfere or whose co-prescription is contraindicated with amitriptyline or trifluoperazine 6.Any patient with ongoing treatment with antidepressants or antipsychotics 7.Any history of hypersensitivity, adverse effect, or ineffectiveness with amitriptyline or trifluoperazine 8.Patients for whom Amitriptyline and Trifluoperazine are contraindicated 9.Elderly patients> 60 years 10.Pregnancy and breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dyspeptic symptom improvement At week 4 and 8 5-point Likert Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events Throughout the study Patient reported adverse events,Change in Likert scale score or persistence of improvement or recurrance At week 12 5-point likert scale | — |
Countries
Bangladesh
Contacts
Public ContactMd. Moktadirul Hoque Shuvo
Dhaka Medical College
Outcome results
None listed