Medication-related osteonecrosis of the jaw in female patient on antiresorptive drugs Bisphosphonate-Associated Osteonecrosis of the Jaw Biomarkers C-terminal type I collagen telopeptide Osteocalcin Serum Saliva
Conditions
Interventions
Healthy female age 40 years old or over
No underlying disease
No current medication
came for routine dental checkup,Female Patients age 40 years old or over and currently on either oral or injectio
Screening,Screening
Control,Sample
Sponsors
Faculty of Dentistry, Mahidol University
Eligibility
Sex/Gender
Female
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients currently on either oral or injection/infusion antiresorptive medication 1.Patients currently receiving either oral or injection/infusion antiresorptive medications, but without symptoms or clinical signs of MRONJ. 2.Patients exhibiting clinical signs of MRONJ in at least one location within the oral cavity.
Exclusion criteria
Exclusion criteria: Patients that 1. has a history of jaw radiotherapy. 2. has an evidence of metastatic disease to the jaws. 3. presence of medications (e.g., warfarin, steroids). 4. has diseases that alter bone turnover marker levels (e.g., diabetes mellitus, liver disease, chronic kidney disease). 5. has other diseases limiting oral health care. 6. use of tobacco products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-terminal telopeptide One time sample collection Enzyme-Linked Immunosorbent Assay | — |
Secondary
| Measure | Time frame |
|---|---|
| Osteocalcin One time sample collection Enzyme-Linked Immunosorbent Assay | — |
Countries
Thailand
Contacts
Public ContactChakorn Vorakulpipat
Faculty of Dentistry, Mahidol University
Outcome results
None listed