Altered pharmacokinetics of vancomycin in critically ill adult patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT). This population is at high risk of suboptimal antibiotic exposure due to impaired renal clearance, severe hypoalbuminemia, and multiple organ dysfunction, which can affect vancomycin distribution and elimination. The study focuses on optimizing dosing to ensure therapeutic drug levels are achieved while minimizing toxicity. Vancomycin, p
Conditions
Interventions
Adult critically ill patients receiving Continuous Renal Replacement Therapy and treated with vancomycin for bacterial infections. This group includes patients with varying severity of organ dysfuncti
Basic Science
POPPK vancomycin
Sponsors
This study does not have an external primary sponsor. The responsibility for initiating, managing, and financing the study lies solely with the principal investigator and their affiliated institution. The investigator ensures that the trial is properly registered and conducted according to all applicable regulations and guidelines.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age greater than or equal to 18 years Diagnosed with acute kidney injury Received continuous renal replacement therapy Treated with intravenous vancomycin At least one vancomycin serum concentration level was measured during the period of CRRT
Exclusion criteria
Exclusion criteria: History of hemodialysis treatment History of peritoneal dialysis treatment History of kidney transplantation History of allergy to vancomycin Received vancomycin through non-intravenous routes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PopPk 24 hour vancomycin concentration | — |
Secondary
| Measure | Time frame |
|---|---|
| Optimal dose estimation using Monte Carlo simulation At the end of the modeling process or after completion of simulation runs (e.g., after 1000 simulations). Calculation of individualized dosing regimens through Monte Carlo simulation modeling based on pharmacokinetic and pharmacodynamic parameters to predict drug concentration profiles. | — |
Countries
Thailand
Contacts
Public ContactChidtawan Hirunsomboon
Mahidol University
Outcome results
None listed