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Randomized cross-over comparison of using continuous positive airway pressure (CPAP) to deep inspiration breath hold technique (DIBH) for reducing mean heart dose in radiotherapy treatment planning of early left-sided breast cancer: A dosimetric study

Randomized cross-over comparison of using continuous positive airway pressure (CPAP) to deep inspiration breath hold technique (DIBH) for reducing mean heart dose in radiotherapy treatment planning of early left-sided breast cancer: A dosimetric study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250608007
Enrollment
32
Registered
2025-06-08
Start date
2021-02-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Left-sided breast cancer in women patients requiring radiotherapy breast cancer radiotherapy continuous positive airway pressure deep inspiration breath hold cardiac dose radiation therapy heart protection left breast cancer CPAP DIBH

Interventions

Deep-inspiration breath-hold (DIBH) technique then Continuous positive airway pressure (CPAP) technique,Continuous positive airway pressure (CPAP) technique then Deep-inspiration breath-hold (DIBH)
Active Comparator Radiation,Active Comparator Radiation
DIBH then CPAP,CPAP then DIBH

Sponsors

Faculty of Medicine, Siriraj Hospital, Mahidol University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Female gender 2. Age 18 years or more 3. Diagnosed with left-sided breast cancer or DCIS who underwent breast-conserving surgery with indication for post-operative breast radiotherapy without lymph node irradiation 4. Able to hold deep inspiration breath for 20-30 seconds

Exclusion criteria

Exclusion criteria: 1. Previous history of chest radiotherapy 2. Bilateral breast cancer 3. History of risk for contact droplet and airborne infections that are expected not to resolve within 7 days before treatment simulation 4. History of COVID-19 infection risk 5. Patients with contraindications for CPAP use including skull base injury, post-surgery with cerebrospinal fluid leakage, active epistaxis 6. Patients with diffuse parenchymal lesions on chest x-ray within 3 months 7. History of uncontrolled airway diseases or severe exacerbation requiring hospitalization within the past year 8. Patients with moderate to severe persistent allergic rhinitis with nasal discharge, sneezing, or nasal congestion affecting daily life or sleep more than 4 days per week and lasting more than 4 weeks

Design outcomes

Primary

MeasureTime frame
Mean heart dose At radiotherapy planning time Gy (radiation dose)—

Secondary

MeasureTime frame
Patient satisfaction Imediately after CT simulation Questionnaire—

Countries

Thailand

Contacts

Public ContactKullathorn Thephamongkhol

Faculty of Medicine, Siriraj Hospital, Mahidol University

kullathorn.the@mahidol.edu024197082

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026