Cancer risks in chronic atrophic gastritis stratified by H. pylori status to identify subtype-specific risks and refine prevention strategies. Cancer risk Chronic atrophic gastritis Helicobacter pylori
Conditions
Interventions
Chronic atrophic gastritis patients with Helicobacter pylori infection.,Chronic atrophic gastritis patients without Helicobacter pylori infection.
Screening,Screening
H. pylori-associated atrophic gastritis ,non-H. pylori-associated atrophic gastritis
Sponsors
Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients who underwent upper esophagogastroduodenoscopy (EGD) with gastric biopsy for dyspepsia diagnosis at Chiang Mai University Hospital, Thailand, between June 2012 and May 2017. 2. No cancer diagnosis within one year following their endoscopic examination. 3. Follow-up period exceeding one year, with data collection continuing until December 31, 2023.
Exclusion criteria
Exclusion criteria: 1. Absence of gastric mucosal biopsy. 2. History of peptic ulcer disease. 3. Previous gastroduodenal surgery. 4. Prior H. pylori eradication therapy. 5. Presence of chronic systemic illnesses requiring long-term medication, including diabetes and cardiovascular disease. 6. Any prior cancer diagnosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cancer diagnosis 1, 2, 3, 4, 5, 6, 7, 8 years after diagnosis of atrophic gastritis Cancer incidence per 100,000 person-years | — |
Secondary
| Measure | Time frame |
|---|---|
| Factors associated with breast cancer 1, 2, 3, 4, 5, 6, 7, 8 years after diagnosis of atrophic gastritis Hazard ratio | — |
Countries
Thailand
Contacts
Public ContactTaned Chitapanarux
Faculty of Medicine, Chiang Mai University
Outcome results
None listed