Adverse events from medication Adverse events
Conditions
Interventions
Oral fosfomycin 3 g PO at day 4,6,Ertapenem 1g IV q 24 hr at day 4-7
Experimental Drug,Active Comparator Drug
Fosfomycin oral,Ertapenem
Sponsors
No
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: adults aged 20 years or older, diagnosed with cUTIs based on criteria including male gender, females aged more than 51 years, presence of an indwelling catheter, renal stones, urinary obstruction, ureteral stents, recent urological surgery past 6 months, neurogenic bladder, immunosuppressive conditions (patients received chemotherapy or prednisolone at a dose of 30 mg or equivalent, or other immunosuppressive drugs, within the last 30 days), or renal transplantation. Patients must have received appropriate antibiotics for at least 3 days and had urine cultures positive for Enterobacterales (E. coli, Enterobacter spp., Citrobacter spp., Proteus spp.) susceptible to both fosfomycin trometamol and carbapenems
Exclusion criteria
Exclusion criteria: allergy to study drugs, resistance to either drug, urine culture yielded Klebsiella pneumoniae(21), creatinine clearance (CrCl) less than 10 mL/min(22,23), bacteremia, pregnancy, co-infection with other organs, hemodynamic instability, recent participation in other clinical trials, or inability to provide consent without a legal representative.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical cure 7 days Clinical assessment | — |
Secondary
| Measure | Time frame |
|---|---|
| microbiological cure 7 days urine culture,clinical cure 28 days clinical assessment,length of stay day Duration of admit,Readmission rate 28 days readmit visit hospital | — |
Countries
Thailand
Contacts
Public ContactKirun Angkanavisan
Phramongkutklao Hospital
Outcome results
None listed