Is epinephrine irrigation effective in reducing blood loss in total knee arthroplasty?: A Triple Blinded randomized controlled trial

Is epinephrine irrigation effective in reducing blood loss in total knee arthroplasty?

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250603007

Enrollment

Registered

2025-06-03

Start date

2025-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee requiring total knee arthroplasty. The study focuses on perioperative blood loss associated with this surgical procedure and investigates methods to reduce blood loss. Excessive blood loss during TKA can increase the risk of complications, require blood transfusions, and delay recovery. The research aims to evaluate whether epinephrine saline lavage can effectively reduce blood loss and related complications in patients undergoing primary total knee replacement. Total

Interventions

Patients in this group will undergo intraoperative intra-articular lavage using a solution prepared by diluting 8 milligrams of epinephrine in 2,000 milliliters of normal saline. The lavage will be pe

Experimental Drug,Placebo Comparator Drug

Epinephrine saline lavage,Normal saline lavage

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Primary osteoarthritis of the knee undergoing cemented unilateral total knee arthroplasty, 2. Age greater than 50 years, 3. American Society of Anesthesiologists (ASA) physical status classification grade I to III

Exclusion criteria

Exclusion criteria: 1. History of thromboembolic disease, 2. Bleeding disorders, 3. Allergy to epinephrine, 4. Revision surgery

Design outcomes

Primary

Measure	Time frame
Total calculated blood loss 48 hours postoperatively Using hemoglobin balance and Nadler formula to estimate blood loss from Hb change and transfused units	—

Secondary

Measure	Time frame
Change in hemoglobin and hematocrit levels 48 hours postoperatively Measurement of hemoglobin and hematocrit levels from venous blood samples taken preoperatively and at 48 hours postoperatively,Incidence of blood transfusion 48 hours postoperatively Number of patients who received any blood component transfusion during hospitalization,Incidence of postoperative complications, including deep vein thrombosis, pulmonary embolism, wound infection, and wound necrosis until hospital discharge Diagnosis confirmed by clinical evaluation and imaging,Volume of postoperative drainage 48 hours postoperatively Cumulative volume of blood collected from the surgical drain	—

Measure

Time frame

Change in hemoglobin and hematocrit levels 48 hours postoperatively Measurement of hemoglobin and hematocrit levels from venous blood samples taken preoperatively and at 48 hours postoperatively,Incidence of blood transfusion 48 hours postoperatively Number of patients who received any blood component transfusion during hospitalization,Incidence of postoperative complications, including deep vein thrombosis, pulmonary embolism, wound infection, and wound necrosis until hospital discharge Diagnosis confirmed by clinical evaluation and imaging,Volume of postoperative drainage 48 hours postoperatively Cumulative volume of blood collected from the surgical drain

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Countries

Thailand

Contacts

Public ContactPiyaphat Charusombat

Lerdsin Hospital

piyaphatcharusombat@gmail.com0810177676

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026