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The Effect of Positioning on the Incidence of Post-Induction Hypotension in Elderly Patients Undergoing Non-Cardiac Surgery : A Randomized Controlled Trial

The Effect of Positioning on the Incidence of Post-Induction Hypotension in Elderly Patients Undergoing Non-Cardiac Surgery : A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250531001
Enrollment
123
Registered
2025-05-31
Start date
2025-05-13
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly patients undergoing elective non-cardiac surgery under general anesthesia Post-induction hypotension, elderly patients, non-cardiac surgery, positioning, leg elevation, head down, supine

Interventions

The entire operating table will be tilted 30 degree head-down using a standard goniometer before induction of anesthesia,Place two standard pillows (30 cm) under the patient&#039
s legs while keeping the operating table in the neutral position before induction of anesthesia,keep operating table in the neutral position throughout the operation
Head down group,Leg elevation group,Supine group

Sponsors

Research Affairs, Faculty of Medicine, Khon Kaen university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Elderly patients (age > 65 years old) 2. ASA Class II-III 3. Scheduled for elective non-cardiac surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1. Patients refuse to participate 2. Patients with cardiac morbidities (impaired contractility with LVEF<50%, secondary-degree symptomatic Mobitz I, II or third-degree AV block, unstable arrhythmias, valvular heart disease, recent myocardial infarction less than 1 month before surgery) 3. Known allergy to study anesthetic drugs 4. Patients at increased risk of aspiration (inadequate fasting time, BMI > 40 kg/m2, GERD, Gut obstruction) 5. Raised intracranial/ocular pressure 6. Severe pulmonary disease (as indicated by a forced expiratory volume in 1 second (FEV1) of < 1.0 l) 7. Combination with neuraxial anesthesia 8. Recent unstable hemodynamic history

Design outcomes

Primary

MeasureTime frame
Incidence of Post-induction hypotension At 1, 3, 5, 10 and 15 minutes after tracheal intubation OR until skin incision OR repositioning for surgery Blood pressure

Secondary

MeasureTime frame
Systolic blood pressure (SBP) At 1, 3, 5, 10 and 15 minutes after tracheal intubation OR until skin incision OR repositioning for surgery Blood pressure,Diastolic blood pressure (DBP) At 1, 3, 5, 10 and 15 minutes after tracheal intubation OR until skin incision OR repositioning for surgery Blood pressure,Mean arterial pressure (MAP) At 1, 3, 5, 10 and 15 minutes after tracheal intubation OR until skin incision OR repositioning for surgery Blood pressure,Heart rate (HR) At 1, 3, 5, 10 and 15 minutes after tracheal intubation OR until skin incision OR repositioning for surgery Heart rate (HR),Patients who required vasopressor administration After the induction of anesthesia Number of patients who required vasopressor administration,Total vasopressor consumption After the induction of anesthesia Total dose of vasopressor

Countries

Thailand

Contacts

Public ContactSiwalai Sucher

Srinagarind hospital

siwalai@kku.ac.th0885523389

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026