Proteomic Profiling in Artificial Endometrial Preparation with Endometrial Compaction Patients Undergoing Single Euploid Embryo Transfer

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250527006

Enrollment

Registered

2025-05-27

Start date

2025-02-21

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A systematic review suggests that endometrial compaction may improve clinical pregnancy rates. This study aims to identify the proteomic profile of patients with endometrial compaction undergoing single euploid embryo transfer during artificial endometrial preparation cycles, aiming to identify molecular markers associated with improved receptivity and implantation outcomes. Proteomics, Artificial Endometrial Preparation, Endometrial compaction, Euploid

Interventions

Uterine fluid will be collected before embryo transfer using a soft catheter aspiration technique. The samples will be analyzed for proteomic profiles to investigate molecular markers associated with

Experimental Procedure/Surgery,Experimental Procedure/Surgery

Uterine fluid,Uterine fluid

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. No more than one previous FET, 2. Single euploid embryo transferred D5-6, 3. Artificial Endometrial Preparation (AEP), 4. Endometrial thickness 8-14 mm

Exclusion criteria

Exclusion criteria: 1. Contraindication for exogenous hormone administration, 2. Uterine anomalies, 3. Intrauterine adhesions, 4. Endometrial polyp, 5. Myoma uteri submucous type or myoma distorted uterine cavity, 6. Hydrosalpinx, 7. Pelvic inflammatory disease or Sexual transmitted disease, 8. Use other medications e.g. Aspirin, Prednisolone, Dexamethasone or Low molecular weight heparin

Design outcomes

Primary

Measure	Time frame
Proteomic profile On the day of embryo transfer Mass spectrometry-based proteomic analysis using LC-MS/MS to quantify protein expression levels	—

Secondary

Measure	Time frame
Clinical pregnancy rate 6 weeks after embryo transfer Positive fetal heartbeat detected by transvaginal ultrasound,Proteomic profile in pregnant EC group On the day of embryo transfer Quantitative proteomic analysis using LC-MS/MS of uterine fluid in women with endometrial compaction who achieved clinical pregnancy	—

Countries

Thailand

Contacts

Public ContactSupanat Boonneramitr

Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University

supabank052@gmail.com0615451939

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026