Acute kidney injury in Sepsis patient Acute Kidney Injury, Sepsis, Thiamine Supplementation, Renal Replacement Therapy, Critical Care, Major Adverse Kidney Events
Conditions
Interventions
received thiamine 200 mg in 100 mL solution in 0.9% sodium chloride infused over 30 minutes intravenously every 12 hours for seven days, in addition to standard sepsis care,standard sepsis care
Active Comparator Drug,No Intervention No treatment
Thiamine supplementation group,Standard care group
Sponsors
Phramongkutklao hospital
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult patients (aged 20 years or more) 2. Sepsis defined according to Sepsis-3 criteria with Sequential Organ Failure Assessment (SOFA) score 2 points or more 3. Suspected or confirmed infection 4. presenting to the emergency department or admitted to inpatient units at Phramongkutklao Hospital
Exclusion criteria
Exclusion criteria: 1. pre-existing AKI as defined by KDIGO criteria at the time of initial assessment 2. chronic kidney disease (CKD) stage 4 or more (eGFR less than 30 mL/min/1.73) or history of renal replacement therapy 3. post-renal or pre-renal AKI 4. cirrhotic patients with Child-Turcotte-Pugh score B or C 5. medical conditions requiring thiamine supplementation as standard care 6. known allergy to thiamine 7. conditions requiring fluid restriction that would prevent standard volume resuscitation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Acute kidney injury(AKI) within 7 days of enrollment AKI defined according to KDIGO criteria(Kidney Disease: Improving Global Outcomes) | — |
Secondary
| Measure | Time frame |
|---|---|
| In-hospital mortality in admission dead,In-hospital Major adverse kidney events (MAKE) within 7 days of enrollment dead, new renal replacement therapy, or persistent renal dysfunction,Renal replacement therapy requirement during hospital stays Renal replacement therapy requirement,Hospital length of stay during hospital stays number of Hospital length of stay,Lactate clearance within 7 days of enrollment calculated Lactate level as percent change in lactate levels from baseline to days 1, 2, 3, and 7. | — |
Countries
Thailand
Contacts
Public Contactbordin tuntianunanon
Phramongkutklao hospital
Outcome results
None listed