Effect of systemic antibiotics on new bone formation after tooth extraction. Bone formation, Systemic antibiotic
Conditions
Interventions
Patients who received 2 g IV ampicillin prior to mandibular molar extraction
30 minutes later, venous blood was drawn to prepare A-PRF, which was placed into the extraction socket, and the socket was approximated/closed with 3-0 silk sutures.,Patients who received 600 mg IM cl
30 minutes later, venous blood was drawn to prepare A-PRF, which was applied to the extraction socket, and the socket was approximated/closed with 3-0 silk sutures. (These patients had a penicillin al
the socket was irrigated with sterile normal saline only and approximated/closed with 3-0 silk sutures. No PRF was used, and no prophylactic/systemic antibiotics were administered.
Group 1,Group 2,Group 3(Control)
Sponsors
Faculty of Dentistry
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 60 years. Patients classified as ASA I or ASA II. Patients with an extraction indication for at least one mandibular molar. Patients receiving prophylactic antibiotic therapy (ampicillin 2 g IV or clindamycin 600 mg IM). Patients with no history of long-term opioid use. Patients without current intraoral infection (e.g., abscess, cellulitis), acute pericoronitis, or osteomyelitis. Patients with no history of antiresorptive/anti-angiogenic therapy (e.g., bisphosphonates, denosumab). Patients with no current smoking or alcohol use.
Exclusion criteria
Exclusion criteria: Patients younger than 18 years or older than 60 years. Patients with a history of long-term opioid use. Patients with current intraoral infection (e.g., abscess, cellulitis), acute pericoronitis, or osteomyelitis. Patients with a history of antiresorptive/anti-angiogenic therapy (e.g., bisphosphonates, denosumab). Patients with active smoking or alcohol use. Patients receiving anticoagulant therapy (e.g., warfarin [Coumadin]). Pregnant or lactating patients. Patients with incomplete examination and control records.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bone density postoperative 1 months panaromic radiograph( Fractal Analysis) | — |
Secondary
| Measure | Time frame |
|---|---|
| bone trabecular pattern postoperative 1 months panaromic radiograph( Fractal Analysis) | — |
Countries
Turkey
Contacts
Public ContactCennet Eroglu
Akdeniz University
Outcome results
None listed