Chronic Rhinosinusitis Nasal polyps Rhinosinusitis Nasal irrigation Hypertonic Saline Solutions Budesonide
Conditions
Interventions
1 mg of budesonide and 9 grams of sodium chloride powder mixed with 3 grams of baking soda
pure sodium bicarbonate in 500 ml of room temperature boiled water Nasal irrigation will be performed on post
Experimental Drug,Active Comparator Drug
Buffered hypertonic saline with budesonide ,Isotonic saline with budesonide
Sponsors
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 85 years 2. Patients was diagnosed with primary chronic rhinosinusitis according to EPOS 2020 guideline 3. Received bilateral endoscopic sinus surgery
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Revision surgery 3. Wegener, sarcoidosis, cystic fibrosis, Kartagener 4. Previous radiotherapy to sinonasal area 5. History of hypersensitivity to budesonide 6. Patients with severe glaucoma 7. Patients with hepatic failure 8. Patients with pituitary tumour
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of inflammatory burden 1, 2, 4 and 6 weeks Lund Kennedy score,Disease specific quality of life Base line, 1, 2, 4 and 6 weeks Thai SNOT-22 | — |
Secondary
| Measure | Time frame |
|---|---|
| Nasal blockage Base line, 1, 2, 4 and 6 weeks VAS score,Alteration in sense of smell Base line, 1, 2, 4 and 6 weeks VAS score,Nasal discharge Base line, 1, 2, 4 and 6 weeks VAS score,Facial pain Base line, 1, 2, 4 and 6 weeks VAS score,Side effects Burning and dryness 1, 2, 4 and 6 weeks Record form | — |
Countries
Thailand
Contacts
Public ContactParamee Leaungchairat
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed