High-dose adenosine as a first-line regimen for stress cardiac magnetic resonance: a multicenter randomized controlled trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250521004

Enrollment

240

Registered

2025-05-21

Start date

2025-09-22

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Suspected or known coronary artery disease adenosine response

Interventions

High-dose adenosine stress regimen with a dose of 210 mcg/kg/min intravenously for 2.0 minutes,High-dose adenosine stress regimen with a dose of 140 mcg/kg/min intravenously for 3.5 minutes

Experimental Drug,Active Comparator Drug

High-dose adenosine,Standard-dose adenosine

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1 Patients aged 18 years or more 2 Known or suspected CAD 3 Undergoing adenosine stress cardiac magnetic resonance imaging

Exclusion criteria

Exclusion criteria: 1 Pregnant woman 2 Individuals contraindicated for gadolinium 3 Individuals contraindicated for adenosine, including those with uncontrolled airway diseases, sick sinus syndrome, or secondary atrioventricular block, Mobitz type II or higher degree 4 Patients with atrial fibrillation 5 Those with LVEF < 40% 6 Individuals with cardiac implantable electronic devices 7 Post-heart transplant patients

Design outcomes

Primary

Measure	Time frame
Efficacy During adenosine administration Adenosine response (increased in heart rate of 10 bpm or more)	—

Secondary

Measure	Time frame
Safety During adenosine administration Adenosine adverse events,Changes in heart rate During adenosine administration Peak minus baseline heart rate,Changes in systolic and diastolic blood pressure During adenosine administration Peak minus baseline blood pressure,Myocardial perfusion reserve During adenosine administration The ratio of myocardial blood flow during stress to the MBF at rest,Time used in the process of stress perfusion scan During adenosine administration Time,Total dose of adenosine used During adenosine administration per kilogram body weight,Potential factors that predict responders Study analysis Multivariable logistic regression model	—

Measure

Time frame

Safety During adenosine administration Adenosine adverse events,Changes in heart rate During adenosine administration Peak minus baseline heart rate,Changes in systolic and diastolic blood pressure During adenosine administration Peak minus baseline blood pressure,Myocardial perfusion reserve During adenosine administration The ratio of myocardial blood flow during stress to the MBF at rest,Time used in the process of stress perfusion scan During adenosine administration Time,Total dose of adenosine used During adenosine administration per kilogram body weight,Potential factors that predict responders Study analysis Multivariable logistic regression model

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Countries

Thailand

Contacts

Public ContactNonthikorn Theerasuwipakorn

King Chulalongkorn Memorial Hospital

n.theerasuwipakorn@gmail.com022564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026