1. Does the muscle stiffness differ among patients with early SSc and healthy population? 2. How are the differences of muscle stiffness among patients with early SSc and healthy population? Ultrasonography, Ultrasound elastography, Shear wave elastography, Systemic sclerosis
Conditions
Interventions
Systemic sclerosis patients, who are followed at Scleroderma clinic,Age and gender matched control cases with healthy status
Diagnostic,Diagnostic
Systemic sclerosis patients,Healthy cases with age and gender-matched
Sponsors
Faculty of Medicine, Khon Kaen university
Eligibility
Sex/Gender
All
Age
18 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1.Systemic sclerosis patients who are diagnosed according to 2013 ACR/EULAR classification criteria for scleroderma, over 18 years old 2.With 5 years of the onset of non-Ranaud's symptoms 3.Stable dose of immunosuppressants for at least 1 month 4.Stable steroid equivalent to prednisolone not excede 10 mg/d for at least 1 month
Exclusion criteria
Exclusion criteria: 1. History of upper or lower extremity fracture 2. History of muscle injury at upper or lower extremity 3. Abnormal CK (Creatine kinase) level 4. Bedridden and confined to no self-care 5. Evidence of active malignant disease 6. Uncontrolled or severe medical problems including diabetes mellitus, asthma, angina, cardiovascular 7. Active peripheral vascular disease that may cause limb and/or muscle ischemia 8. Active infection that needs systemic antibiotic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle stiffness of systemic sclerosis patients and healthy populations At the time, that exam finish. B-mode and Shear (or stiffness) velocities of muscles at both thighs. Skin (epidermis and dermis) thickness and muscle textures were recorded on B-mode | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare muscle stiffness among early systemic sclerosis patients and healthy adults With in 1 year after examination Compare the muscle stiffness (velocity; m/s) among early systemic sclerosis patients and healthy adults | — |
Countries
Thailand
Contacts
Public ContactSudarat Hongchokthavee
Khon Kaen University
Outcome results
None listed