Efficacy of transdermal patch in reducing post-operative pain after total knee arthroplasty: Randomized controlled, Placebo-controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250517002

Enrollment

108

Registered

2025-05-17

Start date

2025-03-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Simultaneous bilateral total knee arthroplasty Osteoarthritis both knees Osteoarthritis of knee, Pain control, Transdermal, Local

Interventions

Esflurbiproffen patch at side of knee after total knee arthroplasty. Chosen side by randomization,Nonmedicined patch (color similar to Esflurbiproffen patch)

Active Comparator Drug,Placebo Comparator Drug

Esflurbiproffen patch,Placebo

Eligibility

Sex/Gender

All

Age

55 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Bilateral total knee arthroplasty patient 2. Age more than 55 years old to 85 years old 3. ASA classification I to III 4. Volunteer or willing to participate

Exclusion criteria

Exclusion criteria: Unicompartmental OA knee 1. History of infection 2. Has contraindication or allergy to NSAID drugs 3. Renal failure or eGFR < 30 mL/kg/1.73m2 4. Any intraoperative complication occured

Design outcomes

Primary

Measure	Time frame
Pain score at 24 , 48,72 and 96 hours after surgery Numeric pain score	—

Secondary

Measure	Time frame
Complication anytime Not statistical method	—

Countries

Thailand

Contacts

Public ContactWarachai Jongjirasiri

Police general hospital

medwarachai@gmail.com0823302951

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026