neurosurgical tumor postoperative complications biomarkers (albumin, albumin-to-globulin ratio, HALP score) brain tumor surgery postoperative outcomes predictive biomarkers albumin albumin-to-globulin ratio HALP score neurosurgical outcomes postoperative complications brain tumor retrospective study perioperative risk factors surgical prognosis
Conditions
Interventions
Adults aged 20 years or older who underwent elective craniotomy for intracranial tumor resection at Maharaj Nakorn Chiang Mai Hospital between January 2023 and December 2025. Preoperative serum albumi
Supportive Care
Elective craniotomy tumor cohort
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult patients (20 years and older) undergoing elective craniotomy for primary or metastatic intracranial tumor resection. 2. Availability of complete preoperative laboratory panel: serum albumin, total protein (for globulin calculation), haemoglobin, WBC differential (lymphocytes), and platelet count , enabling calculation of all three biomarkers. 3. Cases of recurrent tumor requiring re-craniotomy are considered a new entry if the surgery occurs more than 90 days after the initial procedure.
Exclusion criteria
Exclusion criteria: Always excluded because these conditions chronically and independently dominate the study biomarkers: 1. Emergency craniotomy or trauma-related surgery 2. Severe anemia (Hb less than 8.0 g perdL preoperatively) dominates haemoglobin component of HALP 3. Active haemolytic disorder or thalassaemia major, intermedia 4. Haematologic malignancy, independently alters lymphocyte, platelet, and Hgb values 5. Decompensated liver disease (Child-Pugh B, C), severe albumin dysregulation independent of nutrition 6. Active systemic infection or sepsis at time of surgery 7. Advanced or uncontrolled HIV infection: CD4 count less than 200 cells per microL, AIDS-defining illness, or active opportunistic infection 8. Incomplete or missing critical EMR data (cannot compute primary biomarkers or primary outcome) 9. Re-craniotomy within 90 days of a prior procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite postoperative morbidity (CPM) Within 30 days after surgery Incidence (one or more of 18 pre-specified complications) | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital length of stay (LOS) Index hospitalization after craniotomy days,ICU length of stay Index hospitalization after craniotomy Days,30-day unplanned readmission Within 30 days after hospital discharge Incidence,30-day all-cause mortality Within 30 days after surgery Incidence,Severe adverse events (mortality or unplanned reoperation) Within 30 days after surgery Incidence | — |
Countries
Thailand
Contacts
Public ContactAnanchanok Saringcarinkul
Faculty of Medicine, Chiang Mai University
Outcome results
None listed