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The analgesic efficacy of adding an inter-pectoral plane block to a deep serratus anterior plane block for postoperative pain control after breast cancer surgery: A double-blind randomized controlled trial

The analgesic efficacy of adding an inter-pectoral plane block to a deep serratus anterior plane block for postoperative pain control after breast cancer surgery: A double-blind randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250513004
Enrollment
50
Registered
2025-05-13
Start date
2025-07-17
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer breast cancer, analgesic effect, pain, interpectoral plane block, deep serratus anterior plane block

Interventions

The block will perform under sterile technique in supine position with arm in 90 degree abduction, the ultrasound probe was placed in the oblique sagittal plane at the fourth and fifth costal level on
Active Comparator Procedure/Surgery,Experimental Procedure/Surgery
serratus anterior plane block,serratus anterior plane block combined with interpectoral block

Sponsors

Naruemon Vattanasiriporn
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients who plan to undergo unilateral major breast surgery (mastectomy, mastectomy with sentinel lymph node biopsy and modified radical mastectomy) 2. Age 20-75 years 3. ASA physical status 1-3 4. Reading ability is required

Exclusion criteria

Exclusion criteria: 1. Refuse to participate 2. Body weight lower than 35 kg 3. Allergy to study drugs; paracetamol, parecoxib, fentanyl, morphine, naproxen or bupivacaine 4. Contraindication to IPPB or SAPB include skin infection at block site or coagulopathy 5. Inability to cooperate, communication or report pain scores 6. Psychiatric disease

Design outcomes

Primary

MeasureTime frame
Postoperative morphine consumption (milligrams) at 12 hours postoperatively IV patient-controlled analgesia (PCA) device

Secondary

MeasureTime frame
Postoperative morphine consumption at PACU, 6, 24 and 48 hours IV PCA device,pain score at rest and movement at PACU, 6, 12, 24 and 48 hours postoperatively numeric rating scale,Opioid related-side effects such as PONV, sedation score and respiratory depression within 48 hours postoperatively interview,Length of hospital stay Patient will be discharged from hospital from IPD chart,quality of recovery at 24 hours postoperatively QoR-15,Patient satisfaction at 24 hours postoperatively questionnaire interview,First time to require rescue opioid At first tome to require rescue opioid IV PCA device

Countries

Thailand

Contacts

Public ContactSupakorn Somprattana

Faculty of medicine, Khon Kaen University

supakorn.som@kkumail.com0918326221

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026