Dengue shock syndrome patients admitted to the Intensive Care Units Cytokine storm, Dengue, Dengue shock syndrome, Hemoperfusion
Conditions
Interventions
Patient receiving hemoperfusion treatment,Patient not receiving hemoperfusion treatment
Treatment,Treatment
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age at least 20 years old with confirm dengue infection by one of the following methods; Dengue NS1Ag, Anti DENV-IgM/IgG, or PCR for Dengue 2. Diagnosed as severe Dengue (DHF grade III/IV, DSS) with evidence of plasma leakage - Hematocrit rising at least 20% or evidence of fluid accumulation (according to DHF grade III/IV classification of WHO, 2011 SEARO) and clinical include severe bleeding, severe organ involvement (acute hepatitis, acute liver failure, acute kidney injury, myocarditis, encephalitis) 3. Multiorgan failure (more than 2 organ e.g. Respiratory failure, Liver failure, or Renal failure) 4. Admitted in ICU at Chiang Mai University Hospital Chiang Mai, Thailand
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Known case ESRD 3. Malignancy with on Immunotherapy 4. Limited performance status (ECOG at least 3) 5. Incomplete data collection (50% of data) specifically SOFA, APACHE-II score, serum creatinine, CBC, lactate, hs-CRP
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity score 1 month Sequential organ failure assessment (SOFA) score | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient outcomes 1 month Mortality, inflammatory cytokines (lactate, hs-CRP), liver function test, renal function test, and the need for long-term hemodialysis | — |
Countries
Thailand
Contacts
Public ContactPrit Kusirisin
Faculty of Medicine, Chiang Mai University
Outcome results
None listed