Adult patient diagnosis with diabetes and severe lactic acidosis admit at Chiang Mai University Hospital, Jomthong Hospital, and Nakornping Hospital between 1 January 2006 to 31 December 2023 Diabetes
Conditions
Interventions
Use metformin as antidiabetic drug,Use other antidiabetic drugs except metformin
Prevention,Prevention
Metformin users,Non-metformin users
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.) Age at least 20 years 2.) Diagnosis with diabetes 3.) Elevate serum lactate level (over 4 mmol/L) within 12 hours before and after admission. 4.) High anion gap metabolic acidosis
Exclusion criteria
Exclusion criteria: 1.) Chronic kidney disease stages 4 and 5 (Baseline GFR below 30 mL/min/1.73 m2) 2.) No document baseline creatinine within 365 days 3.) Death within 24 hours after admission 4.) Other causes of metabolic acidosis (eg. Ketoacidosis, toxin induce metabolic acidosis) 5.) Admission due to trauma 6.) Receiving immunosuppressive drug (eg. Prednisolone at least 15 mg/day) 7.) Pregnancy 8.) Kidney transplant status 9.) The lack of data on prehospitalization medication for diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of major adverse kidney events (MAKEs) at 30 days 30 days Serum creatinine, the need for kidney replacement therapy (KRT), and mortality status at 30 day after the diagnosis of severe lactic acidosis | — |
Secondary
| Measure | Time frame |
|---|---|
| Risk factors associated with individual components of MAKEs at 30, 60, and 90 days 90 days Serum creatinine, the need for KRT, and mortality status at 30, 60, and 90 days after the diagnosis of severe lactic acidosis | — |
Countries
Thailand
Contacts
Public ContactPrit Kusirisin
Faculty of Medicine, Chiang Mai University
Outcome results
None listed